Rabbit ATP6V1H Polyclonal Antibody | anti-ATP6V1H antibody

Rabbit anti-Homo sapiens (Human) ATP6V1H Polyclonal Antibody

• Gene Names: ATP6V1H; SFD; NBP1; VMA13; CGI-11; MSTP042; SFDbeta; SFDalpha
• Reactivity: Homo sapiens (Human)
• Applications: ELISA, Western Blot
• Purity: Protein A/G
• Synonyms: ATP6V1H; Polyclonal Antibody; Rabbit anti-Homo sapiens (Human) ATP6V1H Polyclonal Antibody; ATP6V1H Antibody; V-type proton ATPase subunit H; V-ATPase subunit H; Nef-binding protein 1; NBP1; Protein VMA13 homolog; V-ATPase 50/57kDa subunits; Vacuolar proton pump subunit H; Vacuolar proton pump subunit SFD; ATP6V1H CGI-11; anti-ATP6V1H antibody

• Host: Rabbit
• Reactivity: Homo sapiens (Human)
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Protein A/G
• Form/Format: Liquid; Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, pH7.4

• Applicable Applications for anti-ATP6V1H antibody: ELISA (EIA), WB (Western Blot) (ensure identification of antigen)
• Immunogen: Recombinant Homo sapiens (Human) ATP6V1H protein
• Conjugation: Non-conjugate
• Modification: Unmodified
• Deliverables: 1. 200ug recombinant immunogen protein/peptide (positive control).; 2. 1mL preimmune serum (negative control); 3. 10mg rabbit polyclonal antibody purified by Protein A/G.
• Quality Guarantee: 1. Antibody purity >90% confirmed by SDS-PAGE.; 2. Antibody titer > 1: 64,000 confirmed by ELISA; 3. Western Blot positive for the immunogen protein (Not applicable for synthetic peptide).
• Complementary Antibody: Customer can choose 1 FREE antibody from the list below. Please specify the catalog # when order:; * 6*His Monoclonal Antibody #MBS1491670; * DYKDDDDK tag Monoclonal Antibody #MBS1493946; * GAPDH Monoclonal Antibody #MBS1495524; * GFP Monoclonal Antibody #MBS1496050; * Myc tag Monoclonal Antibody #MBS1497694; * GST Monoclonal Antibody #MBS1497871; * Sumo tag Monoclonal Antibody #MBS1498878; * Goat Anti-Rabbit IgG (H+L) Antibody; HRP conjugated #MBS7053510; * HA-Tag Monoclonal Antibody #MBS7135631; * E-Tag Monoclonal Antibody #MBS7135632; * TUBA1A Monoclonal Antibody #MBS7135645; * TUBB Monoclonal Antibody #MBS9018332
• Preparation and Storage: Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.

NCBI and Uniprot Product Information

• NCBI GI #: 47717104
• NCBI GeneID: 51606
• NCBI Accession #: NP_057025.2
• NCBI GenBank Nucleotide #: NM_015941.3
• UniProt Accession #: Q9UI12; Q6PK44; Q9H3E3; Q9Y300; B3KMR0
• Molecular Weight: 55,883 Da
• NCBI Official Full Name: V-type proton ATPase subunit H isoform 1
• NCBI Official Synonym Full Names: ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
• NCBI Official Symbol: ATP6V1H
• NCBI Official Synonym Symbols: SFD; NBP1; VMA13; CGI-11; MSTP042; SFDbeta; SFDalpha
• NCBI Protein Information: V-type proton ATPase subunit H; V-ATPase subunit H; nef-binding protein 1; protein VMA13 homolog; vacuolar ATPase subunit H; V-ATPase 50/57 kDa subunits; vacuolar proton pump subunit H; vacuolar ATP synthase subunit H; vacuolar proton pump subunit SFD
• UniProt Protein Name: V-type proton ATPase subunit H
• Protein Family: V-type proton ATPase
• UniProt Gene Name: ATP6V1H
• UniProt Synonym Gene Names: V-ATPase subunit H; NBP1
• UniProt Entry Name: VATH_HUMAN

NCBI Description

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular organelles. V-ATPase-dependent organelle acidification is necessary for multiple processes including protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. The encoded protein is the regulatory H subunit of the V1 domain of V-ATPase, which is required for catalysis of ATP but not the assembly of V-ATPase. Decreased expression of this gene may play a role in the development of type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

Uniprot Description

ATP6V1H: Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes. Belongs to the V-ATPase H subunit family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Energy Metabolism - oxidative phosphorylation; Hydrolase; EC 3.6.3.14

Chromosomal Location of Human Ortholog: 8q11.2

Cellular Component: lysosomal membrane; plasma membrane; vacuolar proton-transporting V-type ATPase, V1 domain; cytosol

Molecular Function: protein binding; ATPase activity; hydrogen ion transporting ATPase activity, rotational mechanism; enzyme regulator activity

Biological Process: interaction with host; vacuolar acidification; viral reproduction; cellular iron ion homeostasis; regulation of catalytic activity; metabolic process; ATP hydrolysis coupled proton transport; insulin receptor signaling pathway; transferrin transport; endocytosis; transmembrane transport; regulation of defense response to virus by virus