Rabbit anti-Human ATP2C1 Polyclonal Antibody | anti-ATP2C1 antibody

ATP2C1 Antibody (C-term)

Cat. Num. AAA9204028

• Gene Names: ATP2C1; HHD; BCPM; PMR1; SPCA1; hSPCA1; ATP2C1A
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Synonyms: ATP2C1; Polyclonal Antibody; ATP2C1 Antibody (C-term); Calcium-transporting ATPase type 2C member 1; ATPase 2C1; ATP-dependent Ca(2+) pump PMR1; KIAA1347; PMR1L; anti-ATP2C1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit Ig
• Specificity: This ATP2C1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 882-909 amino acids from the C-terminal region of human ATP2C1.
• Purity/Purification: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Concentration: Vial Concentration: 0.5 (varies by lot)
• Sequence Positions: 882-909
• Sequence Length: 888

• Applicable Applications for anti-ATP2C1 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB~~1:1000
• Antigen Type: Synthetic Peptide
• Antigen Source: HUMAN
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(ATP2C1 Antibody (C-term) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the ATP2C1 antibody detected the ATP2C1 protein (arrow).)

Related Product Information for anti-ATP2C1 antibody

The protein encoded by this gene belongs to the family of
P-type cation transport ATPases. This magnesium-dependent enzyme
catalyzes the hydrolysis of ATP coupled with the transport of the
calcium. Defects in this gene cause Hailey-Hailey disease, an
autosomal dominant disorder. Alternatively spliced transcript
variants encoding different isoforms have been identified.

Product Categories/Family for anti-ATP2C1 antibody

Metabolism; Signal Transduction

References

Baron, S., et al. Biochim. Biophys. Acta 1798(8):1512-1521(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Tian, H., et al. J. Dermatol. Sci. 58(1):80-82(2010)
Ding, Y.G., et al. Clin. Exp. Dermatol. 34 (8), E968-E971 (2009) :
Nechama, M., et al. BMC Cell Biol. 10, 70 (2009) :

NCBI and Uniprot Product Information

• NCBI GI #: 48762687
• NCBI GeneID: 27032
• NCBI Accession #: NP_001001485.1; NP_001001486.1; NP_001001487.1; NP_001186108.1; NP_001186109.1; NP_001186110.1; NP_001186111.1; NP_001186112.1; NP_001186113.1; NP_001186114.1; NP_055197.2
• NCBI GenBank Nucleotide #: NM_001001485.2
• UniProt Accession #: P98194; O76005; Q86V72; Q86V73; Q8N6V1; Q8NCJ7; B2RAT7; B4DSW3; B7Z3X9; G3XAH8; G8JLN9
• Molecular Weight: 100577
• NCBI Official Full Name: calcium-transporting ATPase type 2C member 1 isoform 1c
• NCBI Official Synonym Full Names: ATPase, Ca++ transporting, type 2C, member 1
• NCBI Official Symbol: ATP2C1
• NCBI Official Synonym Symbols: HHD; BCPM; PMR1; SPCA1; hSPCA1; ATP2C1A
• NCBI Protein Information: calcium-transporting ATPase type 2C member 1
• UniProt Protein Name: Calcium-transporting ATPase type 2C member 1
• Protein Family: Calcium-transporting ATPase
• UniProt Gene Name: ATP2C1
• UniProt Synonym Gene Names: KIAA1347; PMR1L; ATPase 2C1
• UniProt Entry Name: AT2C1_HUMAN

NCBI Description

The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium ions. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Uniprot Description

ATP2C1: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. Defects in ATP2C1 are the cause of Hailey-Hailey disease (HHD); also known as benign familial pemphigus. HHD is an autosomal dominant disorder characterized by persistent blisters and suprabasal cell separation (acantholysis) of the epidermis, due to impaired keratinocyte adhesion. Patients lacking all isoforms except isoform 2 have HHD. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter, ion channel; Hydrolase; Membrane protein, multi-pass; EC 3.6.3.8; Transporter; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q22.1

Cellular Component: Golgi membrane; Golgi apparatus; membrane; integral to membrane; trans-Golgi network

Molecular Function: manganese-transporting ATPase activity; signal transducer activity; calcium-transporting ATPase activity; manganese ion binding; metal ion binding; calcium ion binding; ATP binding

Biological Process: cellular calcium ion homeostasis; Golgi calcium ion homeostasis; epidermis development; positive regulation of I-kappaB kinase/NF-kappaB cascade; metabolic process; calcium ion transport; calcium-dependent cell-cell adhesion; actin cytoskeleton reorganization; manganese ion transport; cellular manganese ion homeostasis; signal transduction; Golgi calcium ion transport; transmembrane transport

Disease: Benign Chronic Pemphigus