Rabbit anti-Human ATP1B3 Polyclonal Antibody | anti-ATP1B3 antibody

ATP1B3 Antibody

Cat. Num. AAA1494866

• Gene Names: ATP1B3; CD298; ATPB-3
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: >95%, Protein G Purified
• Synonyms: ATP1B3; Polyclonal Antibody; ATP1B3 Antibody; Sodium/potassium-transporting ATPase subunit beta-3; Sodium/potassium-dependent ATPase subunit beta-3; ATPB-3; CD_antigen: CD298; anti-ATP1B3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G Purified
• Sequence Length: 279

• Applicable Applications for anti-ATP1B3 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Storage Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Conjugate: Non-conjugated
• Immunogen: Recombinant human Sodium/potassium-transporting ATPase subunit beta-3 protein
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-66341
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human colon cancer using MBS1494866 at dilution of 1:100)

Related Product Information for anti-ATP1B3 antibody

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known.

NCBI and Uniprot Product Information

• NCBI GI #: 4502281
• NCBI GeneID: 483
• NCBI Accession #: NP_001670.1
• NCBI GenBank Nucleotide #: NM_001679.2
• UniProt Accession #: P54709; B7Z1N7
• Molecular Weight: 21,713 Da
• NCBI Official Full Name: sodium/potassium-transporting ATPase subunit beta-3
• NCBI Official Synonym Full Names: ATPase, Na+/K+ transporting, beta 3 polypeptide
• NCBI Official Symbol: ATP1B3
• NCBI Official Synonym Symbols: CD298; ATPB-3
• NCBI Protein Information: sodium/potassium-transporting ATPase subunit beta-3
• UniProt Protein Name: Sodium/potassium-transporting ATPase subunit beta-3
• UniProt Gene Name: ATP1B3
• UniProt Synonym Gene Names: ATPB-3
• UniProt Entry Name: AT1B3_HUMAN

NCBI Description

The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2. [provided by RefSeq, Jul 2008]

Uniprot Description

ATP1B3: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known. Belongs to the X(+)/potassium ATPases subunit beta family.

Protein type: Membrane protein, integral; Transporter

Chromosomal Location of Human Ortholog: 3q23

Cellular Component: caveola; melanosome; plasma membrane; sodium:potassium-exchanging ATPase complex

Molecular Function: ATPase activator activity; ATPase binding; sodium:potassium-exchanging ATPase activity

Biological Process: blood coagulation; cellular potassium ion homeostasis; cellular sodium ion homeostasis; establishment and/or maintenance of transmembrane electrochemical gradient; leukocyte migration; positive regulation of ATPase activity; potassium ion import; protein stabilization; transmembrane transport; transport