Rabbit anti-Human ATP1A3 Polyclonal Antibody | anti-ATP1A3 antibody

ATP1A3, ID (ATP1A3, Sodium/potassium-transporting ATPase subunit alpha-3, Na(+)/K(+) ATPase alpha(III) subunit, Sodium pump subunit alpha-3) (AP)

Cat. Num. AAA6276392

• Gene Names: ATP1A3; RDP; AHC2; CAPOS; DYT12; ATP1A1
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: ATP1A3; Polyclonal Antibody; ID (ATP1A3; Sodium/potassium-transporting ATPase subunit alpha-3; Na(+)/K(+) ATPase alpha(III) subunit; Sodium pump subunit alpha-3) (AP); Sodium pump subunit alpha-3; anti-ATP1A3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

• Applicable Applications for anti-ATP1A3 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: ATP1A3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 805-833 amino acids from the Central region of human ATP1A3.
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(ATP1A3 Antibody (Center) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the ATP1A3 antibody detected the ATP1A3 protein (arrow).)

Related Product Information for anti-ATP1A3 antibody

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+-ATPases. Na+/K+-ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+-ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit.

Product Categories/Family for anti-ATP1A3 antibody

Antibodies; Ion Channel

References

Einholm, A.P., et al. J. Biol. Chem. 285(34):26245-26254(2010). Floyd, R.V., et al. Reprod Sci 17(4):366-376(2010). Hauck, C., et al. Eur. J. Pharmacol. 622 (1-3), 7-14 (2009): Blanco-Arias, P., et al. Hum. Mol. Genet. 18(13):2370-2377(2009). Goldstein, I., et al. Biol. Psychiatry 65(11):985-991(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 22748667
• NCBI GeneID: 478
• NCBI Accession #: NP_689509.1
• NCBI GenBank Nucleotide #: NM_152296.5
• UniProt Accession #: P13637
• Molecular Weight: 111 kDa
• NCBI Official Full Name: sodium/potassium-transporting ATPase subunit alpha-3 isoform 1
• NCBI Official Synonym Full Names: ATPase Na+/K+ transporting subunit alpha 3
• NCBI Official Symbol: ATP1A3
• NCBI Official Synonym Symbols: RDP; AHC2; CAPOS; DYT12; ATP1A1
• NCBI Protein Information: sodium/potassium-transporting ATPase subunit alpha-3
• UniProt Protein Name: Sodium/potassium-transporting ATPase subunit alpha-3
• Protein Family: Sodium/potassium-transporting ATPase
• UniProt Gene Name: ATP1A3
• UniProt Synonym Gene Names: Na(+)/K(+) ATPase alpha-3 subunit
• UniProt Entry Name: AT1A3_HUMAN

NCBI Description

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]