Rabbit anti-Human, Mouse ATP1A2 Polyclonal Antibody | anti-ATP1A2 antibody

ATP1A2-Specific Rabbit Polyclonal

Cat. Num. AAA766926

• Gene Names: ATP1A2; FHM2; MHP2
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: ATP1A2; Polyclonal Antibody; ATP1A2-Specific Rabbit Polyclonal; anti-ATP1A2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 354

• Applicable Applications for anti-ATP1A2 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human skeletal muscle using MBS766926 (ATP1A2-Specific antibody) at dilution of 1:50)

Western Blot (WB)

(mouse brain tissue were subjected to SDS PAGE followed by western blot with MBS766926 (ATP1A2-Specific antibody) at dilution of 1:800)

NCBI and Uniprot Product Information

• NCBI GI #: 957948972
• NCBI GeneID: 477
• Molecular Weight: 112,265 Da
• NCBI Official Full Name: ATPase Na+/K+ transporting alpha 2 polypeptide isoform 2, partial
• NCBI Official Synonym Full Names: ATPase Na+/K+ transporting subunit alpha 2
• NCBI Official Symbol: ATP1A2
• NCBI Official Synonym Symbols: FHM2; MHP2
• NCBI Protein Information: sodium/potassium-transporting ATPase subunit alpha-2
• UniProt Protein Name: Sodium/potassium-transporting ATPase subunit alpha-2
• Protein Family: Sodium/potassium-transporting ATPase
• UniProt Gene Name: ATP1A2
• UniProt Synonym Gene Names: KIAA0778; Na(+)/K(+) ATPase alpha-2 subunit
• UniProt Entry Name: AT1A2_HUMAN

NCBI Description

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. Mutations in this gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood. [provided by RefSeq, Oct 2008]

Uniprot Description

ATP1A2: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients. Defects in ATP1A2 are the cause of familial hemiplegic migraine type 2 (FHM2). FHM2 is a rare, severe, autosomal dominant subtype of migraine characterized by aura and some hemiparesis. Defects in ATP1A2 are a cause of alternating hemiplegia of childhood 1 (AHC1). AHC is typically distinguished from familial hemiplegic migraine by infantile onset of the symptoms and high prevalence of associated neurological deficits that become increasingly obvious with age. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.

Protein type: Membrane protein, multi-pass; Transporter, ion channel; Membrane protein, integral; EC 3.6.3.9; Transporter; Hydrolase

Chromosomal Location of Human Ortholog: 1q23.2

Cellular Component: caveola; cytoplasm; cytosol; dendritic spine; endosome; intracellular membrane-bound organelle; membrane; myelin sheath; plasma membrane; sodium:potassium-exchanging ATPase complex; T-tubule

Molecular Function: ATP binding; ATPase activity; chaperone binding; drug binding; potassium ion binding; protein binding; sodium ion binding; sodium:potassium-exchanging ATPase activity

Biological Process: adult locomotory behavior; ATP hydrolysis coupled proton transport; ATP metabolic process; cardiac muscle contraction; cellular potassium ion homeostasis; cellular sodium ion homeostasis; establishment and/or maintenance of transmembrane electrochemical gradient; locomotion; negative regulation of heart contraction; negative regulation of striated muscle contraction; neurological control of breathing; neurotransmitter uptake; potassium ion import; potassium ion transport; reduction of cytosolic calcium ion concentration; regulation of blood pressure; regulation of glutamate uptake during transmission of nerve impulse; regulation of smooth muscle contraction; regulation of striated muscle contraction; regulation of synaptic transmission, glutamatergic; regulation of the force of heart contraction; regulation of vasoconstriction; response to nicotine; sodium ion transport; visual learning

Disease: Alternating Hemiplegia Of Childhood 1; Migraine, Familial Hemiplegic, 2