Western Blot (WB)
(ATP13A2 Antibody (C-term) western blot analysis in U251 cell line lysates (35ug/lane).This demonstrates the ATP13A2 antibody detected the ATP13A2 protein (arrow).)
Rabbit anti-Human ATP13A2 Polyclonal Antibody | anti-ATP13A2 antibody
ATP13A2, CT (ATP13A2, PARK9, Probable cation-transporting ATPase 13A2)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Western Blot (WB)
(ATP13A2 Antibody (C-term) western blot analysis in U251 cell line lysates (35ug/lane).This demonstrates the ATP13A2 antibody detected the ATP13A2 protein (arrow).)
Western Blot (WB)
(ATP13A2 Antibody (C-term) western blot analysis in U251 cell line lysates (35ug/lane).This demonstrates the ATP13A2 antibody detected the ATP13A2 protein (arrow).)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the P5 subfamily of ATPases which transports inorganic cations as well as other substrates. Mutations in this gene are associated with Kufor-Rakeb syndrome (KRS), also referred to as Parkinson disease 9. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2008]
Uniprot Description
Function: May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity. Ref.12
Catalytic activity: ATP + H2O = ADP + phosphate.
Subcellular location: Membrane; Multi-pass membrane protein
By similarity. Lysosome Ref.11 Ref.12.
Tissue specificity: Expressed in brain; protein levels are markedly increased in brain from subjects with Parkinson disease and subjects with dementia with Lewy bodies. Detected in pyramidal neurons located throughout the cingulate cortex (at protein level). In the substantia nigra, it is found in neuromelanin-positive dopaminergic neurons (at protein level). Ref.12
Involvement in disease: Kufor-Rakeb syndrome (KRS) [MIM:606693]: A rare form of autosomal recessive juvenile or early-onset, levodopa-responsive parkinsonism. In addition to typical parkinsonian signs, clinical manifestations of Kufor-Rakeb syndrome include behavioral problems, facial tremor, pyramidal tract dysfunction, supranuclear gaze palsy, and dementia.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9 Ref.10 Ref.11 Ref.13 Ref.14 Ref.17
Sequence similarities: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. [View classification]
Sequence caution: The sequence CAA08912.1 differs from that shown. Reason: Frameshift at position 1054.
Research Articles on ATP13A2
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Product Notes
The ATP13A2 atp13a2 (Catalog #AAA647093) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ATP13A2, CT (ATP13A2, PARK9, Probable cation-transporting ATPase 13A2) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ATP13A2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in Western Blot, ELISA Dilution: ELISA: 1:1,000 Western Blot: 1:100-500. Researchers should empirically determine the suitability of the ATP13A2 atp13a2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ATP13A2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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