Rabbit anti-Human ATP13A2 Polyclonal Antibody | anti-ATP13A2 antibody

ATP13A2, CT (ATP13A2, PARK9, Probable cation-transporting ATPase 13A2) (FITC)

Cat. Num. AAA6276373

• Gene Names: ATP13A2; CLN12; KRPPD; PARK9; SPG78; HSA9947
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: ATP13A2; Polyclonal Antibody; CT (ATP13A2; PARK9; Probable cation-transporting ATPase 13A2) (FITC); Probable cation-transporting ATPase 13A2; anti-ATP13A2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).
• Sequence Length: 1180

• Applicable Applications for anti-ATP13A2 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: ATP13A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1132-1161 amino acids from the C-terminal region of human ATP13A2.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(ATP13A2 Antibody (C-term) western blot analysis in U251 cell line lysates (35ug/lane).This demonstrates the ATP13A2 antibody detected the ATP13A2 protein (arrow).)

Related Product Information for anti-ATP13A2 antibody

This gene encodes a member of the P5 subfamily of ATPases which transports inorganic cations as well as other substrates. Mutations in this gene are associated with Kufor-Rakeb syndrome (KRS), also referred to as Parkinson disease 9. Multiple transcript variants encoding different isoforms have been found for this gene.

Product Categories/Family for anti-ATP13A2 antibody

Antibodies; Enzymes; ATPase

References

Dos Santos, A.V., et al. Neurosci. Lett. 485(2):121-124(2010). Reetz, K., et al. Neurobiol. Dis. 39(3):402-408(2010). Schneider, S.A., et al. Mov. Disord. 25(8):979-984(2010). Okada, Y., et al. Hum. Mol. Genet. 19(11):2303-2312(2010). Fei, Q.Z., et al. Neurosci. Lett. 475(2):61-63(2010).

NCBI and Uniprot Product Information

• NCBI GI #: 13435129
• NCBI GeneID: 23400
• NCBI Accession #: NP_071372.1; NP_001135446.1
• NCBI GenBank Nucleotide #: NP_071372.1
• UniProt Accession #: Q9NQ11
• NCBI Official Full Name: cation-transporting ATPase 13A2 isoform 1
• NCBI Official Synonym Full Names: ATPase cation transporting 13A2
• NCBI Official Symbol: ATP13A2
• NCBI Official Synonym Symbols: CLN12; KRPPD; PARK9; SPG78; HSA9947
• NCBI Protein Information: cation-transporting ATPase 13A2
• UniProt Protein Name: Cation-transporting ATPase 13A2
• Protein Family: Probable cation-transporting ATPase
• UniProt Gene Name: ATP13A2

NCBI Description

This gene encodes a member of the P5 subfamily of ATPases which transports inorganic cations as well as other substrates. Mutations in this gene are associated with Kufor-Rakeb syndrome (KRS), also referred to as Parkinson disease 9. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2008]

Uniprot Description

ATP13A2: May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity. Expressed in brain; protein levels are markedly increased in brain from subjects with Parkinson disease and subjects with dementia with Lewy bodies. Detected in pyramidal neurons located throughout the cingulate cortex. In the substantia nigra, it is found in neuromelanin- positive dopaminergic neurons. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.6.3.-; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel

Chromosomal Location of Human Ortholog: 1p36.13

Cellular Component: autophagic vacuole; cell soma; integral component of membrane; integral component of plasma membrane; late endosome; lysosomal lumen; lysosomal membrane; lysosome; multivesicular body; neuron projection; transport vesicle; vesicle; vesicle membrane

Molecular Function: ATP binding; ATPase activity; calcium-transporting ATPase activity; cation-transporting ATPase activity; manganese ion binding; protein binding; zinc ion binding

Biological Process: cellular calcium ion homeostasis; cellular cation homeostasis; cellular iron ion homeostasis; cellular zinc ion homeostasis; positive regulation of protein secretion; protein autophosphorylation; regulation of autophagic vacuole size; regulation of endopeptidase activity; regulation of intracellular protein transport; regulation of macroautophagy; zinc ion homeostasis

Disease: Kufor-rakeb Syndrome; Spastic Paraplegia 78, Autosomal Recessive