Rabbit ATG18 Polyclonal Antibody | anti-ATG18 antibody

ATG18 Polyclonal Antibody FITC Conjugated

Cat. Num. AAA9463640

• Gene Names: WIPI1; ATG18; ATG18A; WIPI49
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence
• Purity: affinity purified by Protein A
• Synonyms: ATG18; Polyclonal Antibody; ATG18 Polyclonal Antibody FITC Conjugated; anti-ATG18 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Purity/Purification: affinity purified by Protein A
• Form/Format: 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

• Applicable Applications for anti-ATG18 antibody: Immunofluorescence (IF)
• Application Notes: IF: 1:50-200
• Conjugation: FITC
• Immunogen Type: 361-446/446
• Preparation and Storage: Store at -20 degree C for one year. Avoid repeated freeze/thaw cycles.; Shipped at 4 degree C.

Product Categories/Family for anti-ATG18 antibody

Conjugated Primary Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 157388939
• NCBI GeneID: 55062
• NCBI Accession #: NP_060453
• NCBI GenBank Nucleotide #: NM_017983.5
• UniProt Accession #: Q5MNZ9; Q8IXM5; Q9NWF8
• Molecular Weight: 49 kDa
• NCBI Official Full Name: WD repeat domain phosphoinositide-interacting protein 1
• NCBI Official Synonym Full Names: WD repeat domain, phosphoinositide interacting 1
• NCBI Official Symbol: WIPI1
• NCBI Official Synonym Symbols: ATG18; ATG18A; WIPI49
• NCBI Protein Information: WD repeat domain phosphoinositide-interacting protein 1; WIPI 49 kDa; WIPI-1 alpha; atg18 protein homolog; WD40 repeat protein Interacting with phosphoInositides of 49kDa; WD40 repeat protein interacting with phosphoinositides of 49 kDa
• UniProt Protein Name: WD repeat domain phosphoinositide-interacting protein 1
• Protein Family: Autophagy-related protein
• UniProt Gene Name: WIPI1
• UniProt Synonym Gene Names: WIPI49; WIPI-1; WIPI 49 kDa
• UniProt Entry Name: WIPI1_HUMAN

NCBI Description

WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI1, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]).[supplied by OMIM, Mar 2008]

Uniprot Description

ATG18: May play a role in autophagy. May regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway. Probably interacts with androgen (AR) and the estrogen receptor (ER). Binds PtdIns3P and to a lesser extent, PtdIns3,5P2 and PtdIns5P in vitro. Interaction with PtdIns3P is required for recruitment to membranes. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Autophagy

Chromosomal Location of Human Ortholog: 17q24.2

Cellular Component: Golgi membrane; cytoskeleton; extrinsic to membrane; clathrin-coated vesicle; pre-autophagosomal structure membrane; cytoplasm; endosome membrane; trans-Golgi network; cytosol

Molecular Function: androgen receptor binding; estrogen receptor binding; phosphatidylinositol 3-phosphate binding; receptor binding

Biological Process: cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; unfolded protein response; protein amino acid lipidation; mitochondrion degradation; autophagy; autophagic vacuole formation; cellular response to nitrogen starvation; vesicle targeting, trans-Golgi to endosome