Rabbit anti-Human STMN1 Polyclonal Antibody | anti-STMN1 antibody

STMN1 (Phospho-Ser62) Antibody

Cat. Num. AAA9406634

• Gene Names: STMN1; Lag; SMN; OP18; PP17; PP19; PR22; LAP18; C1orf215
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry
• Purity: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
• Synonyms: STMN1; Polyclonal Antibody; STMN1 (Phospho-Ser62) Antibody; LAG; LAP18; pp19; PR22; STN1; anti-STMN1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of STMN1 only when phosphorylated at serine 63.
• Purity/Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
• Form/Format: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 174

• Applicable Applications for anti-STMN1 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Western blotting: 1:500~1:1000; Immunohistochemistry: 1:50~1:100
• Immunogen Type: Peptide-KLH
• Immunogen Description: Peptide sequence around phosphorylation site of Serine 63(R-K-S(p)-H-E) derived from Human STMN1.
• Modification: Phospho-Ser63
• Target Name: STMN1
• Preparation and Storage: Store at -20 degree C/1 year

Western Blot (WB)

(Western blot analysis of extracts from COS cells treated with nocodazole using STMN1 (Phospho-Ser63) Antibody #.The lane on the right is treated with the antigen-specific peptide.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using STMN1 (Phospho-Ser63) antibody (left)or the same antibody preincubated with blocking peptide (right).)

Related Product Information for anti-STMN1 antibody

This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Alternatively spliced transcript variants encoding the same protein have been identified.

Product Categories/Family for anti-STMN1 antibody

Phospho-specific Ab

NCBI and Uniprot Product Information

• NCBI GI #: 224451142
• NCBI GeneID: 3925
• NCBI Accession #: NP_001138926.1
• NCBI GenBank Nucleotide #: NM_001145454.2
• UniProt Accession #: P16949; A2A2D1; B2R4E7; B7Z8N4; D3DPJ5
• Molecular Weight: 19,824 Da
• NCBI Official Full Name: stathmin isoform b
• NCBI Official Synonym Full Names: stathmin 1
• NCBI Official Symbol: STMN1
• NCBI Official Synonym Symbols: Lag; SMN; OP18; PP17; PP19; PR22; LAP18; C1orf215
• NCBI Protein Information: stathmin
• UniProt Protein Name: Stathmin
• Protein Family: Stathmin
• UniProt Gene Name: STMN1
• UniProt Synonym Gene Names: C1orf215; LAP18; OP18; Op18; pp19
• UniProt Entry Name: STMN1_HUMAN

NCBI Description

This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

Uniprot Description

STMN1: a microtubule-associated protein involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Phosphorylation reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, nonleukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: microtubule; neuron projection; membrane; cytoplasm; intracellular; cytosol

Molecular Function: tubulin binding; signal transducer activity

Biological Process: mitotic spindle organization and biogenesis; axonogenesis; negative regulation of microtubule polymerization; response to virus; microtubule depolymerization; brain development; positive regulation of cell motility; signal transduction; neurite development; regulation of cytoskeleton organization and biogenesis