Rabbit ATAD3A Polyclonal Antibody | anti-ATAD3A antibody

ATAD3A Antibody

Cat. Num. AAA9410518

• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: Affinity chromatography purified via peptide column
• Synonyms: ATAD3A; Polyclonal Antibody; ATAD3A Antibody; ATPase family AAA domain-containing protein 3A; anti-ATAD3A antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: ATAD3A antibody is predicted to not cross-react with other ATAD protein family members. At least two isoforms are known to exist.
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 586

• Applicable Applications for anti-ATAD3A antibody: ELISA (EIA), Western Blot (WB)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a 19 amino acid peptide near the amino terminus of human ATAD3A.
• Target Name: ATAD3A
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of ATAD3A in Daudi cell lysate with ATAD3A antibody at 1 ug/mL.)

Related Product Information for anti-ATAD3A antibody

ATAD3A is a member of the AAA ATPase family, a family of proteins that catalyze ATP into ADP and are involved in several cellular functions such as cell-cycle regulation, protein proteolysis and transport. The AAA ATPase family is characterized by a highly conserved AAA motif containing Walker homology sequences and imparting ATPase activity. Mitochondrial membrane proteins ATAD3A/B contribute to the stabilization of nucleoids and may participate in the transformation pathway and the chemosensitivity of oligodendrogliomas. The gene encoding ATAD3A/B/C maps to human chromosome 1 and has been suggested to be an anti-apoptotic marker.

Product Categories/Family for anti-ATAD3A antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 283436222
• NCBI GeneID: 55210
• NCBI Accession #: NP_001164006.1
• NCBI GenBank Nucleotide #: NM_001170535.1
• UniProt Accession #: Q9NVI7; Q5SV23; Q8N275; Q96A50; B3KPB3; D2K8Q1; G3V1I6
• Molecular Weight: 57,948 Da
• NCBI Official Full Name: ATPase family AAA domain-containing protein 3A isoform 2
• NCBI Official Synonym Full Names: ATPase family, AAA domain containing 3A
• NCBI Official Symbol: ATAD3A
• NCBI Protein Information: ATPase family AAA domain-containing protein 3A
• UniProt Protein Name: ATPase family AAA domain-containing protein 3A
• Protein Family: ATPase family AAA domain-containing protein
• UniProt Gene Name: ATAD3A
• UniProt Entry Name: ATD3A_HUMAN

NCBI Description

ATAD3A and ATAD3B (MIM 612317) are mitochondrial membrane proteins that contribute to the stabilization of large mitochondrial DNA (mtDNA)-protein complexes called nucleoids (He et al., 2007 [PubMed 17210950]).[supplied by OMIM, Sep 2008]

Uniprot Description

ATAD3A: Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. May play an important in mitochondrial protein synthesis. May also participate in mitochondrial DNA replication. May bind to mitochondrial DNA D-loops and contribute to nucleoid stability. Required for enhanced channeling of cholesterol for hormone- dependent steroidogenesis. Belongs to the AAA ATPase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial

Chromosomal Location of Human Ortholog: 1p36.33

Cellular Component: mitochondrion; mitochondrial inner membrane; integral to membrane

Molecular Function: ATP binding

Biological Process: cell growth; negative regulation of apoptosis