Western Blot (WB)
(Western blot analysis of extracts from Mouse brain tissue, using ASIC2 Antibody. The lane on the left was treated with blocking peptide.)
Rabbit ASIC2 Polyclonal Antibody | anti-ASIC2 antibody
ASIC2 Antibody
Predicted: Bovine, Rabbit, Dog, Chicken
Predicted: Bovine, Rabbit, Dog, Chicken
Western Blot (WB)
(Western blot analysis of extracts from Mouse brain tissue, using ASIC2 Antibody. The lane on the left was treated with blocking peptide.)
Western Blot (WB)
(Western blot analysis of extracts from Mouse brain tissue, using ASIC2 Antibody. The lane on the left was treated with blocking peptide.)
Subunit Structure: Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with STOM; this regulates channel activity (By similarity). Interacts with PRKCABP and ASIC3. Heterotrimer of Asic1a-Asic2a interacts with the snake venom mambalgin-1 (PubMed:23034652). Heterotrimer of Asic1a-Asic2a interacts with the snake venom mambalgin-2 and mambalgin-3 (By similarity). Heterotrimer of Asic1a-Asic2b interacts with the snake venom mambalgin-1 and mambalgin-2 (By similarity).
Similarity: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC2 subfamily.
NCBI and Uniprot Product Information
Predicted: 58 kDa
NCBI Description
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Feb 2012]
Uniprot Description
ASIC2: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis; Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Chromosomal Location of Human Ortholog: 17q11.2-q12
Cellular Component: plasma membrane
Molecular Function: amiloride-sensitive sodium channel activity; protein binding
Biological Process: central nervous system development; monovalent inorganic cation transport; peripheral nervous system development; regulation of blood coagulation; regulation of gene expression; sensory perception of sour taste; synaptic transmission
Research Articles on ASIC2
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Product Notes
The ASIC2 asic2 (Catalog #AAA9611591) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ASIC2 Antibody reacts with Human, Mouse, Rat Predicted: Bovine, Rabbit, Dog, Chicken and may cross-react with other species as described in the data sheet. AAA Biotech's ASIC2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500-1:2000. Researchers should empirically determine the suitability of the ASIC2 asic2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ASIC2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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