Rabbit ARL13B Polyclonal Antibody | anti-ARL13B antibody

ARL13B Antibody

Cat. Num. AAA9405292

• Gene Names: ARL13B; JBTS8; ARL2L1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: Affinity purified
• Synonyms: ARL13B; Polyclonal Antibody; ARL13B Antibody; anti-ARL13B antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Purity/Purification: Affinity purified
• Form/Format: PBS, pH 7.4 with 0.02% sodium azide.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 325

• Applicable Applications for anti-ARL13B antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: ELISA: 1:20000-1:80000; WB: 1:500-1:1000
• Immunogen Type: Recombinant Protein
• Immunogen Description: Rabbit polyclonal ARL13B(1) antibody was raised against a recombinate human ARID3A protein 244-421aa (BC104035).
• Target Name: ARL13B
• Preparation and Storage: This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Testing Data

Product Categories/Family for anti-ARL13B antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 292658837
• NCBI GeneID: 200894
• NCBI Accession #: NP_001167622.1
• NCBI GenBank Nucleotide #: NM_001174151.1
• Molecular Weight: 37,087 Da
• NCBI Official Full Name: ADP-ribosylation factor-like protein 13B isoform 3
• NCBI Official Synonym Full Names: ADP-ribosylation factor-like 13B
• NCBI Official Symbol: ARL13B
• NCBI Official Synonym Symbols: JBTS8; ARL2L1
• NCBI Protein Information: ADP-ribosylation factor-like protein 13B
• UniProt Protein Name: ADP-ribosylation factor-like protein 13B
• UniProt Gene Name: ARL13B
• UniProt Synonym Gene Names: ARL2L1; ARL2-like protein 1
• UniProt Entry Name: AR13B_HUMAN

NCBI Description

This gene encodes a member of the ADP-ribosylation factor-like family. The encoded protein is a small GTPase that contains both N-terminal and C-terminal guanine nucleotide-binding motifs. This protein is localized in the cilia and plays a role in cilia formation and in maintenance of cilia. Mutations in this gene are the cause of Joubert syndrome 8. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Uniprot Description

ARL13B: Defects in ARL13B are the cause of Joubert syndrome type 8 (JBTS8). JBTS is an autosomal recessive disorder presenting with cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay. Neuroradiologically, it is characterized by cerebellar vermis hypoplasia/aplasia, thickened and reoriented superior cerebellar peduncles, and an abnormally large interpeduncular fossa, giving the appearance of a molar tooth on transaxial slices (molar tooth sign). Additional variable features include retinal dystrophy and renal disease. Belongs to the small GTPase superfamily. Arf family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: G protein, monomeric; G protein, monomeric, ARF

Chromosomal Location of Human Ortholog: 3q11.1

Cellular Component: intracellular; cilium

Molecular Function: protein binding; GTP binding

Biological Process: formation of radial glial scaffolds; smoothened signaling pathway; dorsal/ventral pattern formation; sensory cilium biogenesis; interneuron migration from the subpallium to the cortex; small GTPase mediated signal transduction; organelle organization and biogenesis; neural tube patterning; cilium biogenesis; heart looping

Disease: Joubert Syndrome 8