60S ribosomal protein L3 Recombinant Protein | RPL3 recombinant protein

Recombinant Human 60S ribosomal protein L3

Cat. Num. AAA1265387

• Gene Names: RPL3; L3; ASC-1; TARBP-B
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: 60S ribosomal protein L3; Recombinant Human 60S ribosomal protein L3; HIV-1 TAR RNA-binding protein B; TARBP-B; RPL3 recombinant protein

• Host: E Coli
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Liquid containing glycerol
• Sequence Positions: 2-247aa; Partial
• Sequence: SHRKFSAPRHGSLGFLPRKRSSRHRGKVKSFPKDDPSKPVHLTAFLGYKAGMTHIVREVDRPGSKVNKKEVVEAVTIVETPPMVVVGIVGYVETPRGLRTFKTVFAEHISDECKRRFYKNWHKSKKKAFTKYCKKWQDEDGKKQLEKDFSSMKKYCQVIRVIAHTQMRLLPLRQKKAHLMEIQVNGGTVAEKLDWARERLEQQVPVNQVFGQDEMIDVIGVTKGKGYKGVTSRWHTKKLPRKTHRG
• Sequence Length: 403

• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

SDS-PAGE

Related Product Information for RPL3 recombinant protein

The L3 protein is a component of the large subunit of cytoplasmic ribosomes.

Product Categories/Family for RPL3 recombinant protein

Epigenetics and Nuclear Signaling

References

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Hum. Retroviruses 11:663-669(1995) A map of 75 human ribosomal protein genes.Kenmochi N., Kawaguchi T., Rozen S., Davis E., Goodman N., Hudson T.J., Tanaka T., Page D.C.Genome Res. 8:509-523(1998) Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing.Odintsova T.I., Muller E.C., Ivanov A.V., Egorov T.A., Bienert R., Vladimirov S.N., Kostka S., Otto A., Wittmann-Liebold B., Karpova G.G.J. Protein Chem. 22:249-258(2003) NOP132 is required for proper nucleolus localization of DEAD-box RNA helicase DDX47.Sekiguchi T., Hayano T., Yanagida M., Takahashi N., Nishimoto T.Nucleic Acids Res. 34:4593-4608(2006) A quantitative atlas of mitotic phosphorylation.Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.Proc. Natl. Acad. Sci. 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Proteomics 96:253-262(2014) Structures of the human and Drosophila 80S ribosome.Anger A.M., Armache J.P., Berninghausen O., Habeck M., Subklewe M., Wilson D.N., Beckmann R.Nature 497:80-85(2013) Frameshift mutation in p53 regulator RPL26 is associated with multiple physical abnormalities and a specific pre-ribosomal RNA processing defect in diamond-blackfan anemia.Gazda H.T., Preti M., Sheen M.R., O'Donohue M.F., Vlachos A., Davies S.M., Kattamis A., Doherty L., Landowski M., Buros C., Ghazvinian R., Sieff C.A., Newburger P.E., Niewiadomska E., Matysiak M., Glader B., Atsidaftos E., Lipton J.M., Gleizes P.E., Beggs A.H.Hum. Mutat. 33:1037-1044(2012) +Additional computationally mapped references.<p>Provides general information on the entry.

NCBI and Uniprot Product Information

• NCBI GI #: 4506649
• NCBI GeneID: 6122
• NCBI Accession #: NP_000958.1
• NCBI GenBank Nucleotide #: NM_000967.3
• UniProt Accession #: P39023; Q15548; Q5I0G0; B2RDV9
• Molecular Weight: 55.4 kDa
• NCBI Official Full Name: 60S ribosomal protein L3 isoform a
• NCBI Official Synonym Full Names: ribosomal protein L3
• NCBI Official Symbol: RPL3
• NCBI Official Synonym Symbols: L3; ASC-1; TARBP-B
• NCBI Protein Information: 60S ribosomal protein L3
• UniProt Protein Name: 60S ribosomal protein L3
• Protein Family: 60S ribosomal protein
• UniProt Gene Name: RPL3
• UniProt Synonym Gene Names: TARBP-B
• UniProt Entry Name: RL3_HUMAN

NCBI Description

Ribosomes, the complexes that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L3P family of ribosomal proteins and it is located in the cytoplasm. The protein can bind to the HIV-1 TAR mRNA, and it has been suggested that the protein contributes to tat-mediated transactivation. This gene is co-transcribed with several small nucleolar RNA genes, which are located in several of this gene's introns. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Uniprot Description

RPL3: The L3 protein is a component of the large subunit of cytoplasmic ribosomes. Belongs to the ribosomal protein L3P family.

Protein type: Ribosomal; Translation; Nucleolus

Chromosomal Location of Human Ortholog: 22q13

Cellular Component: cytoplasm; cytosol; focal adhesion; nucleolus; nucleoplasm; nucleus

Molecular Function: protein binding; RNA binding; structural constituent of ribosome

Biological Process: cellular protein metabolic process; gene expression; mRNA catabolic process, nonsense-mediated decay; ribosomal large subunit assembly and maintenance; selenium metabolic process; selenocysteine metabolic process; SRP-dependent cotranslational protein targeting to membrane; translation; translational elongation; translational initiation; translational termination; viral infectious cycle; viral reproduction; viral transcription