Rabbit Arg3.1 Polyclonal Antibody | anti-ARC antibody

Arg3.1 (ARC, Growth factor ARC, NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone 630103O07 product activity regulated cytoskeletal-associated protein, full insert sequence, 9.5 days embryo parthenogenote cDNA, RIKEN fu

Cat. Num. AAA613469

• Gene Names: ARC; Arg3.1; KIAA0278
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry
• Purity: Affinity Purified; Purified by affinity chromatography.
• Synonyms: Arg3.1; Polyclonal Antibody; Arg3.1 (ARC; Growth factor ARC; NOD-derived CD11c +ve dendritic cells cDNA; RIKEN full-length enriched library; clone 630103O07 product activity regulated cytoskeletal-associated protein; full insert sequence; 9.5 days embryo parthenogenote cDNA; RIKEN fu; Anti -Arg3.1 (ARC; anti-ARC antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Specific for Arg3.1. Species Crossreactivity: Rat and Mouse. Other species not yet tested.
• Purity/Purification: Affinity Purified; Purified by affinity chromatography.
• Form/Format: Reconstitute in 500 ul of sterile water. Centrifuge to remove any insoluble material.

• Applicable Applications for anti-ARC antibody: Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Immunohistochemistry.; Dilution: Immunohistochemistry: Frozen
• Immunogen: A synthetic peptide from the C terminal of human Arg3.1 protein (ARC protein) conjugated to Blue Carrier Protein. The sequence is homologous with mouse and rat form of Arg3.1.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Immunohistochemistry (IHC)

(Immunohistochemical detection of Arg3.1 in free floating cryosectioned rat brain (Cortex) using MBS613469 at a concentration of 2 ug/ml.)

Immunohistochemistry (IHC)

(Immunohistochemical detection of Arg3.1 in free floating cryosectioned rat brain (Cortex) using MBS613469 at a concentration of 2 µg/ml.)

Immunohistochemistry (IHC)

(Immunohistochemical detection of Arg3.1 in free floating cryosectioned rat brain (Cortex) using Rabbit antibody to Arg3.1 (ARC): IgG (R-173-500) at a concentration of 2 µg/ml.)

Immunohistochemistry (IHC)

(Immunohistochemical detection of Arg3.1 in free floating cryosectioned rat spinal cord (ventral horn) MBS613469 at a concentration of 2 µg/ml.)

Immunohistochemistry (IHC)

(Immunohistochemical detection of Arg3.1 in free floating cryosectioned rat spinal cord (dorsal horn) using MBS613469 at a concentration of 2 µg/ml.)

Related Product Information for anti-ARC antibody

Arc (also termed activity-regulated cytoskeleton-associated protein or Arg3.1), is an effector immediate early gene whose upregulation has been demonstrated during events of synaptic plasticity. Arg3.1 expression is detectable in neuronal cell bodies and dendrites in the brain regions including striatum and cortex hippocampus, hypothalamus, amygdala.

Product Categories/Family for anti-ARC antibody

Antibodies; Abs to Protein Kinases

NCBI and Uniprot Product Information

• NCBI GI #: 8567330
• NCBI GeneID: 23237
• NCBI Accession #: NP_056008.1
• NCBI GenBank Nucleotide #: NM_015193.3
• UniProt Accession #: Q7LC44; Q9UJW6; Q9Y469
• Molecular Weight: 45,316 Da
• NCBI Official Full Name: activity-regulated cytoskeleton-associated protein
• NCBI Official Synonym Full Names: activity-regulated cytoskeleton-associated protein
• NCBI Official Symbol: ARC
• NCBI Official Synonym Symbols: Arg3.1; KIAA0278
• NCBI Protein Information: activity-regulated cytoskeleton-associated protein; ARC/ARG3.1; OTTHUMP00000165993; activity-regulated gene 3.1 protein homolog
• UniProt Protein Name: Activity-regulated cytoskeleton-associated protein
• Protein Family: AAA ATPase forming ring-shaped complexes
• UniProt Gene Name: ARC
• UniProt Synonym Gene Names: KIAA0278
• UniProt Entry Name: ARC_HUMAN

Uniprot Description

ARG3.1: Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. Belongs to the ARC/ARG3.1 family.

Chromosomal Location of Human Ortholog: 8q24.3

Cellular Component: postsynaptic membrane; cytoplasm; postsynaptic density; dendritic spine; acrosome; plasma membrane; cell junction; endosome; actin cytoskeleton

Biological Process: anterior/posterior pattern formation; cell migration; regulation of cell morphogenesis; endocytosis; cytoskeleton organization and biogenesis; learning; regulation of neuronal synaptic plasticity; endoderm development