Rabbit Apolipoprotein E Receptor 2 Polyclonal Antibody | anti-APOER2 antibody

Apolipoprotein E Receptor 2 Antibody

Cat. Num. AAA9231319

• Gene Names: LRP8; MCI1; LRP-8; APOER2; HSZ75190
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, ELISA
• Synonyms: Apolipoprotein E Receptor 2; Polyclonal Antibody; Apolipoprotein E Receptor 2 Antibody; Purified Rabbit Polyclonal Antibody (Pab); Low-density lipoprotein receptor-related protein 8; LRP-8; Apolipoprotein E receptor 2; LRP8; APOER2; anti-APOER2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: KLH conjugated synthetic peptide derived from human Apolipoprotein E Receptor 2
• Form/Format: Supplied in 0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%
• Sequence Length: 904

• Applicable Applications for anti-APOER2 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:500
• Antigen Type: synthetic peptide
• Antigen Region: 441 - 500 aa
• Tissue Location: Expressed mainly in brain and placenta. Also expressed in platelets and megakaryocytic cells. Not expressed in the liver.
• Cellular Location: Cell membrane; Single-pass type I membrane protein. Secreted Note=Isoforms that contain the exon coding for a furin-type cleavage site are proteolytically processed, leading to a secreted receptor fragment.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Western Blot (WB)

(Jurkat)

Related Product Information for anti-APOER2 antibody

Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor.

References

Kim D.-H.,et al.J. Biol. Chem. 271:8373-8380(1996). Kim D.-H.,et al.J. Biol. Chem. 272:8498-8504(1997). Korschineck I.,et al.J. Biol. Chem. 276:13192-13197(2001). Gregory S.G.,et al.Nature 441:315-321(2006). Clatworthy A.E.,et al.Neuroscience 90:903-911(1999).

NCBI and Uniprot Product Information

• NCBI GI #: 65301119
• NCBI GeneID: 7804
• NCBI Accession #: NP_001018064.1
• NCBI GenBank Nucleotide #: NM_001018054.2
• UniProt Accession #: Q14114; O14968; Q86V27; Q99876; Q9BR78; B1AMT6; B1AMT7; B1AMT8
• Molecular Weight: 126 KDa
• NCBI Official Full Name: low-density lipoprotein receptor-related protein 8 isoform 4
• NCBI Official Synonym Full Names: LDL receptor related protein 8
• NCBI Official Symbol: LRP8
• NCBI Official Synonym Symbols: MCI1; LRP-8; APOER2; HSZ75190
• NCBI Protein Information: low-density lipoprotein receptor-related protein 8
• UniProt Protein Name: Low-density lipoprotein receptor-related protein 8
• UniProt Gene Name: LRP8
• UniProt Synonym Gene Names: APOER2; LRP-8

NCBI Description

This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011]

Uniprot Description

Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor. Not required for endocytic uptake of SEPP1 in the kidney which is mediated by LRP2 ().