Immunohistochemistry (IHC)
(Immunohistochemistry Analysis: Representative lot data. Paraffin-embedded hepatocytes in normal human liver was prepared using heat-induced epitope retrieval in citrate buffer, pH 6.0. Immunostaining was performed using a 1:200 dilution of Apolipoprotein C-III. Reactivity was detected using the IHC-Select Detection Kit Immunohistochemistry Analysis: Representative lot data. Paraffin-embedded hepatocytes in normal human liver was prepared using heat-induced epitope retrieval in citrate buffer, pH 6.0. Immunostaining was performed using a 1:200 dilution of Apolipoprotein C-III. Reactivity was detected using the IHC-Select Detection Kit)
Rabbit anti-Human APOC3 Polyclonal Antibody | anti-APOC3 antibody
APOC3 (Apolipoprotein C-III, Apo-CIII, ApoC-III, Apolipoprotein C3) (FITC)
Applications are based on unconjugated antibody.
Immunohistochemistry (IHC)
(Immunohistochemistry Analysis: Representative lot data. Paraffin-embedded hepatocytes in normal human liver was prepared using heat-induced epitope retrieval in citrate buffer, pH 6.0. Immunostaining was performed using a 1:200 dilution of Apolipoprotein C-III. Reactivity was detected using the IHC-Select Detection Kit Immunohistochemistry Analysis: Representative lot data. Paraffin-embedded hepatocytes in normal human liver was prepared using heat-induced epitope retrieval in citrate buffer, pH 6.0. Immunostaining was performed using a 1:200 dilution of Apolipoprotein C-III. Reactivity was detected using the IHC-Select Detection Kit)
Immunohistochemistry (IHC)
(Immunohistochemistry Analysis: Representative lot data. Paraffin-embedded hepatocytes in normal human liver was prepared using heat-induced epitope retrieval in citrate buffer, pH 6.0. Immunostaining was performed using a 1:200 dilution of Apolipoprotein C-III. Reactivity was detected using the IHC-Select Detection Kit Immunohistochemistry Analysis: Representative lot data. Paraffin-embedded hepatocytes in normal human liver was prepared using heat-induced epitope retrieval in citrate buffer, pH 6.0. Immunostaining was performed using a 1:200 dilution of Apolipoprotein C-III. Reactivity was detected using the IHC-Select Detection Kit)
Western Blot (WB)
(Western Blotting Analysis: Representative lot data. Normal human sera was probed with Anti-Apolipoprotein C-III (0.1ug/ml). Proteins were visualized using a Donkey Anti-Rabbit IgG secondary antibody conjugated to HRP and a chemiluminescence detection system. Arrow indicates Apolipoprotein C-III (~14kD).)
Western Blot (WB)
(Western Blotting Analysis: Representative lot data. Normal human sera was probed with Anti-Apolipoprotein C-III (0.1ug/ml). Proteins were visualized using a Donkey Anti-Rabbit IgG secondary antibody conjugated to HRP and a chemiluminescence detection system. Arrow indicates Apolipoprotein C-III (~14kD).)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein component of triglyceride (TG)-rich lipoproteins (TRLs) including very low density lipoproteins (VLDL), high density lipoproteins (HDL) and chylomicrons. The encoded protein plays a role in role in the metabolism of these TRLs through multiple modes. This protein has been shown to promote the secretion of VLDL1, inhibit lipoprotein lipase enzyme activity, and delay catabolism of TRL remnants. Mutations in this gene are associated with low plasma triglyceride levels and reduced risk of ischemic cardiovascular disease, and hyperalphalipoproteinemia, which is characterized by elevated levels of high density lipoprotein (HDL) and HDL cholesterol in human patients. This gene and other related genes comprise an apolipoprotein gene cluster on chromosome 11. [provided by RefSeq, Sep 2017]
Uniprot Description
APOC3: Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles. Defects in APOC3 are the cause of hyperalphalipoproteinemia type 2 (HALP2). HALP2 is a condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels. Belongs to the apolipoprotein C3 family.
Protein type: Secreted; Secreted, signal peptide; Lipid-binding
Chromosomal Location of Human Ortholog: 11q23.3
Cellular Component: extracellular space; chylomicron; early endosome; extracellular region
Molecular Function: lipase inhibitor activity; cholesterol binding; phospholipid binding; enzyme regulator activity
Biological Process: response to drug; cholesterol metabolic process; response to peptide hormone stimulus; phototransduction, visible light; regulation of Cdc42 protein signal transduction; lipoprotein metabolic process; cholesterol efflux; G-protein coupled receptor protein signaling pathway; cholesterol homeostasis; triacylglycerol metabolic process; reverse cholesterol transport; negative regulation of lipid catabolic process; phospholipid efflux; lipoprotein transport; triacylglycerol catabolic process; negative regulation of lipoprotein lipase activity; negative regulation of receptor-mediated endocytosis; negative regulation of lipid metabolic process; retinoid metabolic process; inflammatory response; triacylglycerol mobilization; negative regulation of fatty acid biosynthetic process; response to nutrient
Disease: Apolipoprotein C-iii Deficiency
Research Articles on APOC3
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Product Notes
The APOC3 apoc3 (Catalog #AAA6444548) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The APOC3 (Apolipoprotein C-III, Apo-CIII, ApoC-III, Apolipoprotein C3) (FITC) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's APOC3 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Paraffin, Western Blot (WB). IHC-P: 1:200 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the APOC3 apoc3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "APOC3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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