Goat anti-Mouse APOB48R Polyclonal Antibody | anti-APOBR antibody

APOB48R (Apob48r, Apolipoprotein B48 Receptor, Apob-48)

Cat. Num. AAA619415

• Gene Names: APOBR; APOB48R; APOB100R
• Reactivity: Mouse
• Applications: ELISA
• Purity: Affinity Purified; Purified by Immunoaffinity chromatography.
• Synonyms: APOB48R; Polyclonal Antibody; APOB48R (Apob48r; Apolipoprotein B48 Receptor; Apob-48); Anti -APOB48R (Apob48r; anti-APOBR antibody

• Host: Goat
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes APOB48R. Sequence homology: mouse, rat, dog.
• Purity/Purification: Affinity Purified; Purified by Immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.

• Applicable Applications for anti-APOBR antibody: ELISA (EL/EIA)
• Application Notes: Suitable for use in ELISA.; Dilution: ELISA: 1:32,000
• Immunogen: Synthetic peptide corresponding to C-QELQARLSQPKPQ, from the C Terminus of mouse APOB48R (NP_612183.1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-APOBR antibody

Apo B exists in human plasma as two isoforms: apo B48 and apo B100. Apo B100 is the major physiological ligand for the LDL receptor. It contains 4536 amino acid residues. Apo B100 is the full length protein. Its gene has been mapped on the short arm of chromosome 2, with an approximate length of 43 kilobases and 29 exons. The LDL-binding domain of the molecule is proposed to be located between the aa3129-3532. Apo B100 is synthesized in the liver. It is required for the assembly of very low density lipoproteins (VLDL). It does not interchange between lipoprotein particles, as do the other lipoproteins. It is found in IDL and LDL particles after the removal of the apolipoproteins A, E and C. Apo B48 is present in chylomicrons and chylomicron remnants. It plays an essential role in the intestinal absorption of dietary fats. Apo B48 is synthesized in the small intestine. It comprises the N-terminal 48% of apo B100. Apo B48 is the degraded protein. Apo B48 lacks the LDL receptor-binding domain of Apo B100. It is produced due to post-transscriptional Apo B100 mRNA editing at codon 2153, which creates a stop codon in the intestine instead of a glutamine in the liver.

Product Categories/Family for anti-APOBR antibody

Antibodies; Abs to Lipoproteins

NCBI and Uniprot Product Information

• NCBI GI #: 340138932
• NCBI GeneID: 55911
• NCBI Accession #: NP_061160.3
• NCBI GenBank Nucleotide #: NM_018690.3
• UniProt Accession #: Q0VD83; Q0VD81; Q8NC15; Q9NPJ9; Q9NS13
• Molecular Weight: 114,820 Da
• NCBI Official Full Name: apolipoprotein B receptor
• NCBI Official Synonym Full Names: apolipoprotein B receptor
• NCBI Official Symbol: APOBR
• NCBI Official Synonym Symbols: APOB48R; APOB100R
• NCBI Protein Information: apolipoprotein B receptor; apoB-48R; apolipoprotein B48 receptor; apolipoprotein B-48 receptor; apolipoprotein B100 receptor; apolipoprotein B-100 receptor
• UniProt Protein Name: Apolipoprotein B receptor
• Protein Family: Apolipoprotein B receptor
• UniProt Gene Name: APOBR
• UniProt Synonym Gene Names: APOB48R
• UniProt Entry Name: APOBR_HUMAN

NCBI Description

Apolipoprotein B48 receptor is a macrophage receptor that binds to the apolipoprotein B48 of dietary triglyceride (TG)-rich lipoproteins. This receptor may provide essential lipids, lipid-soluble vitamins and other nutrients to reticuloendothelial cells. If overwhelmed with elevated plasma triglyceride, the apolipoprotein B48 receptor may contribute to foam cell formation, endothelial dysfunction, and atherothrombogenesis. [provided by RefSeq]

Uniprot Description

APOB48R: Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG- VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macrophages. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.

Chromosomal Location of Human Ortholog: 16p11

Cellular Component: chylomicron; membrane; plasma membrane

Molecular Function: very-low-density lipoprotein receptor activity

Biological Process: receptor-mediated endocytosis; cholesterol metabolic process; triacylglycerol metabolic process; lipid transport