Rabbit anti-Mouse APBA2 Polyclonal Antibody | anti-APBA2 antibody

APBA2, ID (APBA2, MINT2, X11L, Amyloid beta A4 precursor protein-binding family A member 2, Adapter protein X11beta, Neuron-specific X11L protein, Neuronal Munc18-1-interacting protein 2) (FITC)

Cat. Num. AAA6274162

• Gene Names: APBA2; X11L; MINT2; LIN-10; HsT16821; X11-BETA; D15S1518E; MGC:14091
• Reactivity: Mouse
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: APBA2; Polyclonal Antibody; ID (APBA2; MINT2; X11L; Amyloid beta A4 precursor protein-binding family A member 2; Adapter protein X11beta; Neuron-specific X11L protein; Neuronal Munc18-1-interacting protein 2) (FITC); Neuronal Munc18-1-interacting protein 2; anti-APBA2 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-APBA2 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: APBA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 314-344 amino acids from the Central region of human APBA2.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(APBA2 Antibody (Center) western blot analysis in mouse cerebellum tissue lysates (35ug/lane).This demonstrates the APBA2 antibody detected the APBA2 protein (arrow).)

Related Product Information for anti-APBA2 antibody

The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

Product Categories/Family for anti-APBA2 antibody

Antibodies; Amyloid

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Swistowski, A., et al. J. Neurosci. 29(50):15703-15712(2009). Mitchell, J.C., et al. Hum. Mol. Genet. 18(23):4492-4500(2009). Babatz, T.D., et al. Autism Res 2(6):359-364(2009). Chang, S.J., et al. BMC Genomics 10, 613 (2009).

NCBI and Uniprot Product Information

• NCBI GI #: 22035550
• NCBI GeneID: 321
• NCBI Accession #: NP_005494.2; NP_001123886.1
• NCBI GenBank Nucleotide #: NM_005503.3
• UniProt Accession #: Q99767; O60571; Q5XKC0; E9PGI4
• Molecular Weight: 81,129 Da
• NCBI Official Full Name: amyloid beta A4 protein-binding family A member 2 isoform a
• NCBI Official Synonym Full Names: amyloid beta (A4) precursor protein-binding, family A, member 2
• NCBI Official Symbol: APBA2
• NCBI Official Synonym Symbols: X11L; MINT2; LIN-10; HsT16821; X11-BETA; D15S1518E; MGC:14091
• NCBI Protein Information: amyloid beta A4 precursor protein-binding family A member 2; mint-2; X11-like protein; adapter protein X11beta; neuron-specific X11L protein; neuronal munc18-1-interacting protein 2; phosphotyrosine-binding/-interacting domain (PTB)-bearing protein; amylo
• UniProt Protein Name: Amyloid beta A4 precursor protein-binding family A member 2
• Protein Family: Amyloid beta A4 precursor protein-binding family
• UniProt Gene Name: APBA2
• UniProt Synonym Gene Names: MINT2; X11L; Mint-2
• UniProt Entry Name: APBA2_HUMAN

NCBI Description

The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

APBA2: Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP. Part of a multimeric complex containing STXBP1 and syntaxin-1. Binds to the cytoplasmic domain of amyloid protein beta, and to the nuclear factor NF-kappa-B/p65 via its PDZ domain. Interacts with the N-terminal domain of APBA2BP. Brain.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 15q11-q12

Cellular Component: plasma membrane

Molecular Function: protein binding; beta-amyloid binding

Biological Process: nervous system development; synaptic transmission; protein transport; in utero embryonic development; regulation of gene expression; multicellular organism growth; locomotory behavior