Rabbit APBA2 Polyclonal Antibody | anti-APBA2 antibody

APBA2 Polyclonal Antibody

Cat. Num. AAA2519427

• Gene Names: APBA2; X11L; MINT2; LIN-10; HsT16821; X11-BETA; D15S1518E; MGC:14091
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: APBA2; Polyclonal Antibody; APBA2 Polyclonal Antibody; X11L; MINT2; LIN-10; HsT16821; X11-BETA; D15S1518E; MGC:14091; anti-APBA2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 2.8mg/mL (varies by lot)
• Sequence Length: 737

• Applicable Applications for anti-APBA2 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:100-1:300
• Immunogen: Synthetic peptide of human APBA2
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using APBA2 Polyclonal Antibody at dilution 1:80)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using APBA2 Polyclonal Antibody at dilution 1:80)

Related Product Information for anti-APBA2 antibody

The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Multiple transcript variants encoding different isoforms have been found for this gene.

Product Categories/Family for anti-APBA2 antibody

Neuroscience

NCBI and Uniprot Product Information

• NCBI GI #: 194353992
• NCBI GeneID: 321
• NCBI Accession #: NP_001123886.1
• NCBI GenBank Nucleotide #: NM_001130414.1
• Molecular Weight: 81,129 Da
• NCBI Official Full Name: amyloid beta A4 protein-binding family A member 2 isoform b
• NCBI Official Synonym Full Names: amyloid beta (A4) precursor protein-binding, family A, member 2
• NCBI Official Symbol: APBA2
• NCBI Official Synonym Symbols: X11L; MINT2; LIN-10; HsT16821; X11-BETA; D15S1518E; MGC:14091
• NCBI Protein Information: amyloid beta A4 precursor protein-binding family A member 2; X11-like protein; adapter protein X11beta; amyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like); mint-2; neuron-specific X11L protein; neuronal munc18-1-interacting protein 2; phosphotyrosine-binding/-interacting domain (PTB)-bearing protein
• UniProt Protein Name: Amyloid beta A4 precursor protein-binding family A member 2
• Protein Family: Amyloid beta A4 precursor protein-binding family
• UniProt Gene Name: APBA2
• UniProt Synonym Gene Names: MINT2; X11L; Mint-2
• UniProt Entry Name: APBA2_HUMAN

NCBI Description

The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

APBA2: Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP. Part of a multimeric complex containing STXBP1 and syntaxin-1. Binds to the cytoplasmic domain of amyloid protein beta, and to the nuclear factor NF-kappa-B/p65 via its PDZ domain. Interacts with the N-terminal domain of APBA2BP. Brain.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 15q11-q12

Cellular Component: plasma membrane

Molecular Function: protein binding; beta-amyloid binding

Biological Process: nervous system development; synaptic transmission; protein transport; regulation of gene expression; in utero embryonic development; multicellular organism growth; locomotory behavior