Western Blot (WB)
(AP4B1 Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the AP4B1 antibody detected the AP4B1 protein (arrow).)
Rabbit AP4B1 Polyclonal Antibody | anti-AP4B1 antibody
AP4B1 Antibody (Center)
Western Blot (WB)
(AP4B1 Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the AP4B1 antibody detected the AP4B1 protein (arrow).)
Western Blot (WB)
(AP4B1 Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the AP4B1 antibody detected the AP4B1 protein (arrow).)
integral membrane proteins at various stages of the endocytic and
secretory pathways. AP4 is composed of 2 large chains, beta-4
(AP4B1) and epsilon-4 (AP4E1; MIM 607244), a medium chain, mu-4
(AP4M1; MIM 602296), and a small chain, sigma-4 (AP4S1; MIM
607243).
Cayrol, C., et al. Biochem. Biophys. Res. Commun. 298(5):720-730(2002)
Takatsu, H., et al. Biochem. Biophys. Res. Commun. 284(4):1083-1089(2001)
Hirst, J., et al. Mol. Biol. Cell 10(8):2787-2802(1999)
Dell'Angelica, E.C., et al. J. Biol. Chem. 274(11):7278-7285(1999)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a subunit of a heterotetrameric adapter-like complex 4 that is involved in targeting proteins from the trans-Golgi network to the endosomal-lysosomal system. Mutations in this gene are associated with cerebral palsy spastic quadriplegic type 5 (CPSQ5) disorder. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Uniprot Description
AP4B1: Subunit of novel type of clathrin- or non-clathrin- associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. Defects in AP4B1 are the cause of cerebral palsy spastic quadriplegic type 5 (CPSQ5). CPSQ5 is a neurodevelopmental disorder characterized by neonatal hypotonia that progresses to hypertonia and spasticity, and severe mental retardation with poor or absent speech development. Belongs to the adaptor complexes large subunit family.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 1p13.2
Cellular Component: clathrin adaptor complex; coated pit; trans-Golgi network
Molecular Function: transporter activity; protein transporter activity
Biological Process: vesicle-mediated transport; intracellular protein transport
Disease: Spastic Paraplegia 47, Autosomal Recessive
Research Articles on AP4B1
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Product Notes
The AP4B1 ap4b1 (Catalog #AAA9206522) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 492-520. The AP4B1 Antibody (Center) reacts with Human (Predicted Reactivity: Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's AP4B1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the AP4B1 ap4b1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "AP4B1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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