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Rabbit anti-Human, Mouse AP1G2 Polyclonal Antibody | anti-AP1G2 antibody

AP1G2 Antibody

Gene Names
AP1G2; G2AD
Reactivity
Human, Mouse
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
AP1G2; Polyclonal Antibody; AP1G2 Antibody; AP-1 complex subunit gamma-like 2; Ap1g2; AP1G2_HUMAN; G2ad; Gamma2-adaptin; anti-AP1G2 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
AP1G2 Antibody detects endogenous levels of AP1G2.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-AP1G2 antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human AP1G2.
Conjugation
Unconjugated
Similarity
Belongs to the adaptor complexes large subunit family.
Subunit Structure
Probably interacts with AP1S1/Sigma1A-adaptin AP1S2/Sigma1B-adaptin. Probably does not interact with APB1. Binds ubiquitin.(Microbial infection) Interacts with HBV major surface antigen L. Interacts with HBV core protein C in a ubiquitin-dependent manner.
Tissue Specificity
Expressed in all but one (skeletal muscle) tissues examined.
Function
May function in protein sorting in late endosomes or multivesucular bodies (MVBs).(Microbial infection) Involved in MVB-assisted maturation of hepatitis B virus (HBV).
Note
Mainly localized to perinuclear vesicular structures (PubMed:9733768). Colocalizes with HBV major surface antigen L and HBV core protein C in CD63-containing compartments (PubMed:16867982). Colocalizes with HBV major surface antigen L to cis-Golgi-like structures (PubMed:11333915).
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
87,117 Da
NCBI Official Full Name
AP-1 complex subunit gamma-like 2 isoform 1
NCBI Official Synonym Full Names
adaptor-related protein complex 1, gamma 2 subunit
NCBI Official Symbol
AP1G2
NCBI Official Synonym Symbols
G2AD
NCBI Protein Information
AP-1 complex subunit gamma-like 2; gamma2-adaptin; clathrin-associated/assembly/adaptor protein, large, gamma-2
UniProt Protein Name
AP-1 complex subunit gamma-like 2
Protein Family
UniProt Gene Name
AP1G2
UniProt Synonym Gene Names
G2ad
UniProt Entry Name
AP1G2_HUMAN

NCBI Description

Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is compsed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This protein along with the complex is thought to function at some trafficking step in the complex pathways between the trans-Golgi network and the cell surface. Several alternatively spliced transcript variants of this gene exist, but their full-length nature is not known. [provided by RefSeq, Aug 2013]

Uniprot Description

AP1G2: May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV). Belongs to the adaptor complexes large subunit family.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: Golgi apparatus; transport vesicle; AP-1 adaptor complex; membrane; endosome membrane; Golgi-associated vesicle

Molecular Function: protein binding; protein transporter activity

Biological Process: vesicle-mediated transport; intracellular protein transport; viral reproduction

Research Articles on AP1G2

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Product Notes

The AP1G2 ap1g2 (Catalog #AAA9630373) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The AP1G2 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's AP1G2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the AP1G2 ap1g2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "AP1G2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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