Immunohistochemistry (IHC)
(Immunohistochemical staining with MBS618260 in formalin-fixed, paraffin-embedded normal colon tissue at 1:100 dilution.)
Rabbit anti-Human Anterior Gradient 2 Polyclonal Antibody | anti-AGR2 antibody
Anterior Gradient 2 (AG-2, AGR2, Secreted Cement Gland Protein XAG-2 Homolog, HPC8)
Gene Names
AGR2; AG2; GOB-4; HAG-2; XAG-2; PDIA17
Reactivity
Human
Applications
ELISA, Immunohistochemistry
Purity
Affinity PurifiedPurified by Protein G affinity chromatography.
Synonyms
Anterior Gradient 2; Polyclonal Antibody; Anterior Gradient 2 (AG-2; AGR2; Secreted Cement Gland Protein XAG-2 Homolog; HPC8); Anti -Anterior Gradient 2 (AG-2; anti-AGR2 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human Anterior Gradient 2. Species Sequence Homology: mouse (88%) and bovine (94%)
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a liquid in PBS, 0.05% sodium azide, 0.2% gelatin.
Applicable Applications for anti-AGR2 antibody
ELISA (EL/EIA), Immunohistochemistry (IHC)
Application Notes
Suitable for use in ELISA and Immunohistochemistry.
Dilution: ELISA: 1:100-1:1000
Immunohistochemistry (Paraffin): 1:100
Dilution: ELISA: 1:100-1:1000
Immunohistochemistry (Paraffin): 1:100
Immunogen
Synthetic peptide corresponding to aa55-72, TQTYEEALYKSKTSNKPL, of human Anterior Gradient 2 (Genbank accession no. NP_006399.1) Cellular Localization: Secreted
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunohistochemistry (IHC)
(Immunohistochemical staining with MBS618260 in formalin-fixed, paraffin-embedded normal colon tissue at 1:100 dilution.)
Immunohistochemistry (IHC)
(Immunohistochemical staining with MBS618260 in formalin-fixed, paraffin-embedded normal colon tissue at 1:100 dilution.)
Related Product Information for anti-AGR2 antibody
AG-2 and AG-3 are recently discovered human homologues of the secreted Xenopus laevis proteins XAG-1/2 (AGR-1/2) that are expressed in the cement gland, an ectodermal organ in the head associated with anteroposterior fate determination during early development(1). Although the roles of AG-2 and AG-3 in mammalian cells are unknown, both proteins share a high degree of protein sequence homology and lie adjacent to one another on chromosome 7p21.
Product Categories/Family for anti-AGR2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
19,979 Da
NCBI Official Full Name
anterior gradient protein 2 homolog
NCBI Official Synonym Full Names
anterior gradient homolog 2 (Xenopus laevis)
NCBI Official Symbol
AGR2
NCBI Official Synonym Symbols
AG2; GOB-4; HAG-2; XAG-2; PDIA17
NCBI Protein Information
anterior gradient protein 2 homolog; AG-2; HPC8; OTTHUMP00000116014; OTTHUMP00000201755; anterior gradient 2 homolog; secreted cement gland homolog; secreted cement gland protein XAG-2 homolog; protein disulfide isomerase family A, member 17
UniProt Protein Name
Anterior gradient protein 2 homolog
Protein Family
UniProt Gene Name
AGR2
UniProt Synonym Gene Names
AG2
UniProt Entry Name
AGR2_HUMAN
Uniprot Description
AGR2: Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells. Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Interacts with LYPD3 and DAG1 (alphaDAG1). Interacts with MUC2; disulfide-linked. Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas, kidney, fetal kidney, testis, placenta, thyroid gland and in estrogen receptor (ER)-positive breast cancer cell lines. Belongs to the AGR family.
Protein type: Secreted; Secreted, signal peptide; Oncoprotein
Chromosomal Location of Human Ortholog: 7p21.3
Cellular Component: mitochondrion; endoplasmic reticulum; extracellular region
Molecular Function: protein binding
Research Articles on AGR2
Similar Products
Product Notes
The AGR2 agr2 (Catalog #AAA618260) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anterior Gradient 2 (AG-2, AGR2, Secreted Cement Gland Protein XAG-2 Homolog, HPC8) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Anterior Gradient 2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Immunohistochemistry (IHC). Suitable for use in ELISA and Immunohistochemistry. Dilution: ELISA: 1:100-1:1000 Immunohistochemistry (Paraffin): 1:100. Researchers should empirically determine the suitability of the AGR2 agr2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Anterior Gradient 2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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