Western Blot (WB)
(Anti-Annexin A1 antibody, MBS175224, Western blottingLane 1: U87 Cell LysateLane 2: HELA Cell LysateLane 3: PANC Cell LysateLane 4: COLO320 Cell LysateLane 5: SMMC Cell Lysate )
Rabbit anti-Human Annexin A1 Polyclonal Antibody | anti-ANXA1 antibody
Anti-Annexin A1 antibody
Western Blot (WB)
(Anti-Annexin A1 antibody, MBS175224, Western blottingLane 1: U87 Cell LysateLane 2: HELA Cell LysateLane 3: PANC Cell LysateLane 4: COLO320 Cell LysateLane 5: SMMC Cell Lysate )
Western Blot (WB)
(Anti-Annexin A1 antibody, MBS175224, Western blottingLane 1: U87 Cell LysateLane 2: HELA Cell LysateLane 3: PANC Cell LysateLane 4: COLO320 Cell LysateLane 5: SMMC Cell Lysate )
Immunohistochemistry (IHC)
(Anti-Annexin A1 antibody, MBS175224, IHC(P)IHC(P): Human Placenta Tissue )
Immunohistochemistry (IHC)
(Anti-Annexin A1 antibody, MBS175224, IHC(P)IHC(P): Human Placenta Tissue )
Immunohistochemistry (IHC)
(Anti-Annexin A1 antibody, MBS175224, IHC(P)IHC(P): Human Tonsil Tissue )
Immunohistochemistry (IHC)
(Anti-Annexin A1 antibody, MBS175224, IHC(P)IHC(P): Human Tonsil Tissue )
Background: Annexin I, also known as lipocortin I(Lipo1), belongs to the family of annexins. These proteins are though to control the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes. In two lipocortins(I and II) a short amino-terminal sequence distinct from the core structure has potential regulatory functions which are dependent on its phosphorylation state. The gene in the mouse encodes a protein of 346 amino acid residues. Mouse Lipo1 gene spans about 17 kb and is divided into 13 exons. Annexin I gene, mapped to 9q11-q22, is located on mouse chromosome 19. Annexin I acts through the formyl peptide receptor on human neutrophils. Peptides derived from the unique N-terminal domain of annexin I serve as FPR ligands and trigger different signaling pathways in a dose-dependent manner.
NCBI and Uniprot Product Information
NCBI Description
Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity. [provided by RefSeq, Jul 2008]
Uniprot Description
ANXA1: a calcium/phospholipid-binding protein with which promotes membrane fusion and is involved in endocytosis. Has anti-inflammatory properties and inhibits phospholipase A2 activity. Accumulates on internalized vesicles after EGF-stimulated endocytosis, suggesting that it may be required for a late stage in inward vesiculation. Phosphorylated by PKC, EGFR and Chak1. Phosphorylation results in loss of the inhibitory activity. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.
Protein type: Lipid-binding; Calcium-binding
Chromosomal Location of Human Ortholog: 9q21.13
Cellular Component: extracellular space; protein complex; cell surface; mast cell granule; focal adhesion; basolateral plasma membrane; extracellular region; cornified envelope; cilium; mitochondrial membrane; cytoplasm; plasma membrane; nucleus; endosome; sarcolemma; vesicle
Molecular Function: protein binding, bridging; protein homodimerization activity; calcium-dependent phospholipid binding; phospholipase A2 inhibitor activity; calcium ion binding; helicase activity; calcium-dependent protein binding; protein binding; single-stranded RNA binding; double-stranded DNA-dependent ATPase activity; phospholipid binding; structural molecule activity; single-stranded DNA binding; receptor binding
Biological Process: response to drug; prostate gland development; response to peptide hormone stimulus; positive regulation of neutrophil apoptosis; gliogenesis; positive regulation of vesicle fusion; alpha-beta T cell differentiation; neutrophil homeostasis; signal transduction; arachidonic acid secretion; endocrine pancreas development; DNA duplex unwinding; response to estradiol stimulus; regulation of cell proliferation; keratinocyte differentiation; cell surface receptor linked signal transduction; insulin secretion; DNA strand renaturation; peptide cross-linking; inflammatory response; cell motility; response to X-ray; positive regulation of prostaglandin biosynthetic process; negative regulation of apoptosis
Research Articles on ANXA1
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Product Notes
The ANXA1 anxa1 (Catalog #AAA175224) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Annexin A1 antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Annexin A1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin. Researchers should empirically determine the suitability of the ANXA1 anxa1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Annexin A1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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