Rabbit ANAPC15 Polyclonal Antibody | anti-ANAPC15 antibody

ANAPC15 Antibody

Cat. Num. AAA9417284

• Gene Names: ANAPC15; APC15; HSPC020; C11orf51
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: ANAPC15; Polyclonal Antibody; ANAPC15 Antibody; APC15; HSPC020; C11orf51; anti-ANAPC15 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total ANAPC15 protein.
• Purity/Purification: Antigen affinity purification
• Form/Format: Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
• Concentration: 1.2mg/ml (varies by lot)
• Sequence Length: 125

• Applicable Applications for anti-ANAPC15 antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1: 30-150
• Immunogen: Synthetic peptide of human ANAPC15
• Immunogen Type: Peptide
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using ANAPC15 Antibody at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200))

Immunohistochemistry (IHC)

(The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using ANAPC15 Antibody at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200))

Related Product Information for anti-ANAPC15 antibody

ANAPC15 is a component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, it plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating to the responsiveness of the spindle assembly checkpoint. It is also required for degradation of CDC20.

Product Categories/Family for anti-ANAPC15 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 511094008
• NCBI GeneID: 25906
• NCBI Accession #: NP_001265414.1
• NCBI GenBank Nucleotide #: NM_001278485.1
• UniProt Accession #: P60006; Q9CXK2; Q9Y269; G3V1Q3
• Molecular Weight: 14,716 Da
• NCBI Official Full Name: anaphase-promoting complex subunit 15 isoform a
• NCBI Official Synonym Full Names: anaphase promoting complex subunit 15
• NCBI Official Symbol: ANAPC15
• NCBI Official Synonym Symbols: APC15; HSPC020; C11orf51
• NCBI Protein Information: anaphase-promoting complex subunit 15
• UniProt Protein Name: Anaphase-promoting complex subunit 15
• UniProt Gene Name: ANAPC15
• UniProt Synonym Gene Names: C11orf51; APC15
• UniProt Entry Name: APC15_HUMAN

Uniprot Description

APC15: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating to the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20. Belongs to the APC15 family.

Chromosomal Location of Human Ortholog: 11q13.4

Cellular Component: anaphase-promoting complex; cytosol; intracellular; nucleoplasm

Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of ubiquitin-protein ligase activity during mitotic cell cycle