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Immunohistochemistry (IHC) (Immunohistochemical analysis of paraffin-embedded Human brain tissue using at dilution 1/50.)

Rabbit anti-Human, Mouse AMBRA1 Polyclonal Antibody | anti-AMBRA1 antibody

AMBRA1 Antibody

Gene Names
AMBRA1; DCAF3; WDR94
Reactivity
Human, Mouse
Applications
Immunohistochemistry
Purity
Antigen affinity purification.
Synonyms
AMBRA1; Polyclonal Antibody; AMBRA1 Antibody; DCAF3; WDR94; anti-AMBRA1 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Specificity
The antibody detects endogenous levels of total AMBRA1 protein.
Purity/Purification
Antigen affinity purification.
Form/Format
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Concentration
1.9 mg/ml (varies by lot)
Sequence Length
1301
Applicable Applications for anti-AMBRA1 antibody
Immunohistochemistry (IHC)
Application Notes
Immunohistochemistry: 1:50-1:200
Immunogen Type
Recombinant Protein
Immunogen Description
Fusion protein corresponding to a region derived from internal residues of human autophagy/beclin-1 regulator 1
Target Name
AMBRA1
Preparation and Storage
Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human brain tissue using at dilution 1/50.)

Immunohistochemistry (IHC) (Immunohistochemical analysis of paraffin-embedded Human brain tissue using at dilution 1/50.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using at dilution 1/50.)

Immunohistochemistry (IHC) (Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using at dilution 1/50.)
Related Product Information for anti-AMBRA1 antibody
Human AMBRA1, which encodes a deduced 1,269-amino acid protein. Ambra1 was expressed throughout development in mice, with strong staining in the neuroepithelium. Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation. Interacts with BECN1. Probably forms a complex with BECN1 and PIK3C3.
Product Categories/Family for anti-AMBRA1 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
84,428 Da
NCBI Official Full Name
activating molecule in BECN1-regulated autophagy protein 1 isoform 1
NCBI Official Synonym Full Names
autophagy/beclin-1 regulator 1
NCBI Official Symbol
AMBRA1
NCBI Official Synonym Symbols
DCAF3; WDR94
NCBI Protein Information
activating molecule in BECN1-regulated autophagy protein 1
UniProt Protein Name
Activating molecule in BECN1-regulated autophagy protein 1
UniProt Gene Name
AMBRA1
UniProt Synonym Gene Names
KIAA1736
UniProt Entry Name
AMRA1_HUMAN

Uniprot Description

AMBRA1: a WD40 protein that regulates autophagy and development of the nervous system. A highly conserved vertebrate protein whose expression is mostly confined to the neuroepithelium during early neurogenesis. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation. Interacts with ATG6. Forms a complex with ATG6 and PIK3C3. Its functional inactivation in mouse is lethal in utero (starting from embryonic day 14.5), leading to severe neural tube defects associated with autophagy impairment, accumulation of ubiquitinated proteins, and excessive apoptosis. Hyperproliferation followed by a wave of caspase-dependent cell death was the earliest detectable abnormality in the developing neuroepithelium. Five isoforms of the human protein are produced by alternative splicing.

Protein type: Autophagy; Vesicle

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: mitochondrial outer membrane; intracellular membrane-bound organelle; mitochondrion; cytoplasm; autophagic vacuole; phagocytic vesicle; axoneme; cytosol

Molecular Function: protein binding; ubiquitin protein ligase binding

Biological Process: neural tube development; negative regulation of cell proliferation; autophagy; positive regulation of phosphoinositide 3-kinase activity; negative regulation of neuron apoptosis; cell differentiation

Research Articles on AMBRA1

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Product Notes

The AMBRA1 ambra1 (Catalog #AAA9402295) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The AMBRA1 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's AMBRA1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). Immunohistochemistry: 1:50-1:200. Researchers should empirically determine the suitability of the AMBRA1 ambra1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "AMBRA1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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