Rabbit anti-Human AMACR Polyclonal Antibody | anti-AMACR antibody

AMACR Antibody, FITC conjugated

Cat. Num. AAA7047674

• Gene Names: AMACR; RM; RACE; CBAS4; P504S; AMACRD
• Reactivity: Human
• Applications: ELISA
• Purity: >95%, Protein G purified
• Synonyms: AMACR; Polyclonal Antibody; AMACR Antibody; FITC conjugated; Alpha-methylacyl-CoA racemase; 2-methylacyl-CoA racemase; anti-AMACR antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G purified
• Form/Format: Liquid
• Sequence Length: 394

• Applicable Applications for anti-AMACR antibody: ELISA (EIA)
• Immunogen: Recombinant human Alpha-methylacyl-CoA racemase protein (13-175AA)
• Preservative: 0.03% Proclin 300
• Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Conjugation: FITC
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-107916
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Related Product Information for anti-AMACR antibody

Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers.

NCBI and Uniprot Product Information

• NCBI GI #: 266456254
• NCBI GeneID: 23600
• NCBI Accession #: NP_001161067.1
• NCBI GenBank Nucleotide #: NM_001167595.1
• UniProt Accession #: Q9UHK6; O43673; Q3KT79; Q96GH1; Q9Y3Q1; A5YM47; B8Y916; B8Y918; F8W9N1
• Molecular Weight: 43,860 Da
• NCBI Official Full Name: alpha-methylacyl-CoA racemase isoform 3
• NCBI Official Synonym Full Names: alpha-methylacyl-CoA racemase
• NCBI Official Symbol: AMACR
• NCBI Official Synonym Symbols: RM; RACE; CBAS4; P504S; AMACRD
• NCBI Protein Information: alpha-methylacyl-CoA racemase
• UniProt Protein Name: Alpha-methylacyl-CoA racemase
• Protein Family: Alpha-methylacyl-CoA racemase
• UniProt Gene Name: AMACR
• UniProt Entry Name: AMACR_HUMAN

NCBI Description

This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene. [provided by RefSeq, Mar 2011]

Uniprot Description

AMACR: Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers. Belongs to the CaiB/BaiF CoA-transferase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 5.1.99.4; Isomerase; Lipid Metabolism - primary bile acid biosynthesis; Mitochondrial

Chromosomal Location of Human Ortholog: 5p13

Cellular Component: cytoplasm; mitochondrion; peroxisomal matrix; peroxisome

Molecular Function: alpha-methylacyl-CoA racemase activity; receptor binding

Biological Process: bile acid biosynthetic process; bile acid metabolic process; fatty acid beta-oxidation using acyl-CoA oxidase

Disease: Alpha-methylacyl-coa Racemase Deficiency; Bile Acid Synthesis Defect, Congenital, 4