Rabbit anti-Mouse, Rat POMK Polyclonal Antibody | anti-POMK antibody

POMK Polyclonal Antibody

Cat. Num. AAA2555724

• Gene Names: POMK; SGK196; MDDGA12; MDDGC12
• Reactivity: Mouse, Rat
• Applications: Western Blot
• Purity: Affinity Purification
• Synonyms: POMK; Polyclonal Antibody; POMK Polyclonal Antibody; FLJ23356; MDDGA12; Probable inactive protein kinase-like protein SgK196; Protein kinase like protein SgK196; Protein kinase-like protein SgK196; Protein O-mannose kinase; SG196; SGK196; Sugen kinase 196; anti-POMK antibody

• Host: Rabbit
• Reactivity: Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Form/Format: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 350

• Applicable Applications for anti-POMK antibody: Western Blot (WB)
• Application Notes: WB: 1:200-1:2000
• Immunogen: Recombinant protein of human POMK
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using POMK antibody.)

Related Product Information for anti-POMK antibody

This gene encodes a protein that may be involved in the presentation of the laminin-binding O-linked carbohydrate chain of alpha-dystroglycan (a-DG), which forms transmembrane linkages between the extracellular matrix and the exoskeleton. Some pathogens use this O-linked carbohydrate unit for host entry. Loss of function compound heterozygous mutations in this gene were found in a human patient affected by the Walker-Warburg syndrome (WWS) phenotype. Mice lacking this gene contain misplaced neurons (heterotopia) in some regions of the brain, possibly from defects in neuronal migration. Alternative splicing of this gene results in multiple transcript variants.

Product Categories/Family for anti-POMK antibody

Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 485836935
• NCBI GeneID: 84197
• NCBI Accession #: NP_001264900.1
• NCBI GenBank Nucleotide #: NM_001277971.1
• UniProt Accession #: Q9H5K3
• Molecular Weight: Calculated: 40kDa; Observed: 45kDa
• NCBI Official Full Name: protein O-mannose kinase
• NCBI Official Synonym Full Names: protein-O-mannose kinase
• NCBI Official Symbol: POMK
• NCBI Official Synonym Symbols: SGK196; MDDGA12; MDDGC12
• NCBI Protein Information: protein O-mannose kinase
• UniProt Protein Name: Protein O-mannose kinase
• Protein Family: Protein O-mannose kinase
• UniProt Gene Name: POMK
• UniProt Synonym Gene Names: SGK196; POMK

NCBI Description

This gene encodes a protein that may be involved in the presentation of the laminin-binding O-linked carbohydrate chain of alpha-dystroglycan (a-DG), which forms transmembrane linkages between the extracellular matrix and the exoskeleton. Some pathogens use this O-linked carbohydrate unit for host entry. Loss of function compound heterozygous mutations in this gene were found in a human patient affected by the Walker-Warburg syndrome (WWS) phenotype. Mice lacking this gene contain misplaced neurons (heterotopia) in some regions of the brain, possibly from defects in neuronal migration. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]

Uniprot Description

Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif.