Rabbit GABA B Receptor 2 Polyclonal Antibody | anti-GABA antibody

GABA B Receptor 2 Rabbit pAb

Cat. Num. AAA8808398

• Gene Names: GABBR2; HG20; GPR51; GPRC3B; GABABR2; HRIHFB2099
• Reactivity: Human, Rat, Mouse
• Synonyms: GABA B Receptor 2; Polyclonal Antibody; GABA B Receptor 2 Rabbit pAb; GABBR2;Gamma aminobutyric acid B receptor 2;GB2;HG20; anti-GABA antibody

• Host: Rabbit
• Reactivity: Human, Rat, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Form/Format: PBS with 0.02% sodium azide and 50% glycerol pH7.4.
• Concentration: 1mg/ml (varies by lot)

• Species: Human
• Immunogen: Synthetic Peptide
• Preparation and Storage: Store at -20 degree C. Avoid repeated freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Rat BrainTissue using GABA B Receptor 2 (EA288) Rabbit pAb diluted at 1:200.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Mouse BrainTissue using GABA B Receptor 2 (EA288)Rabbit pAb diluted at 1:200.)

Related Product Information for anti-GABA antibody

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

NCBI and Uniprot Product Information

• NCBI GI #: 40255245
• NCBI GeneID: 9568
• NCBI Accession #: NP_005449.5
• NCBI GenBank Nucleotide #: NM_005458.7
• UniProt Accession #: O75899; O75974; O75975; Q5VXZ2; Q8WX04; Q9P1R2; Q9UNR1; Q9UNS9
• Molecular Weight: 105,821 Da
• NCBI Official Full Name: gamma-aminobutyric acid type B receptor subunit 2
• NCBI Official Synonym Full Names: gamma-aminobutyric acid (GABA) B receptor, 2
• NCBI Official Symbol: GABBR2
• NCBI Official Synonym Symbols: HG20; GPR51; GPRC3B; GABABR2; HRIHFB2099
• NCBI Protein Information: gamma-aminobutyric acid type B receptor subunit 2; gb2; GABA-BR2; GABA-B-R2; GABA-B receptor 2; GABA-B receptor, R2 subunit; G protein-coupled receptor 51; G-protein coupled receptor 51; gamma-aminobutyric acid B receptor 2
• UniProt Protein Name: Gamma-aminobutyric acid type B receptor subunit 2
• UniProt Gene Name: GABBR2
• UniProt Synonym Gene Names: GPR51; GPRC3B; GABA-B receptor 2; GABA-B-R2; GABA-BR2; GABABR2; Gb2
• UniProt Entry Name: GABR2_HUMAN

NCBI Description

The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.[provided by RefSeq, Jan 2010]

Uniprot Description

GABBR2: Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high- voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Interacts with ATF4 via its C-terminal region. Highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla. Weakly expressed in heart, testis and skeletal muscle. Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.

Protein type: GPCR, family 3; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 9q22.1-q22.3

Cellular Component: postsynaptic membrane; neuron projection; integral to plasma membrane; cytoplasm; plasma membrane; cell junction

Molecular Function: protein binding; GABA-B receptor activity

Biological Process: synaptic transmission; G-protein coupled receptor protein signaling pathway; negative regulation of adenylate cyclase activity; gamma-aminobutyric acid signaling pathway

Disease: Tobacco Addiction, Susceptibility To