Testing Data
Rabbit anti-Human alpha-Fodrin Polyclonal Antibody | anti-Sptan1 antibody
alpha-Fodrin Antibody
Gene Names
Sptan1; Spna2; Spna-2; 2610027H02Rik
Reactivity
Human
Applications
Western Blot, Immunohistochemistry
Purity
Affinity purified
Synonyms
alpha-Fodrin; Polyclonal Antibody; alpha-Fodrin Antibody; SPTAN1; FLJ44613; SPTA2; ; anti-Sptan1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Affinity purified
Form/Format
100 ug (0.5 mg/ml) affinity purified rabbit anti-alpha-Fodrin polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Appearance: Colorless liquid
Appearance: Colorless liquid
Concentration
0.5 mg/ml (varies by lot)
Sequence Length
2472
Applicable Applications for anti-Sptan1 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
Western blot analysis (0.5-4 ug/ml) and in in Immunohistochemistry (10-20 ug/ml).
Immunogen
Synthetic peptide surrounding amino acid 162 of mouse alpha-Fodrin
Handling
The antibody solution should be gently mixed before use.
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Shelf Life: 12 months
Testing Data
Testing Data
Related Product Information for anti-Sptan1 antibody
Background: Fodrin is a universally expressed membrane-associated cytoskeletal protein consisting of alpha- and beta-subunits. The protein is important for maintaining normal membrane structure and supporting cell surface protein function. alpha-Fodrin is one of the important targets cleaved by caspases during apoptosis. The full length 240 kDa protein can be cleaved at several sites within its sequence by activated caspases generating N-terminal 150 kDa, C-terminal 120 kDa, and 35 kDa major products. Cleavage of alpha-Fodrin leads to membrane malfunction and cell shrinkage.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
282,340 Da
NCBI Official Full Name
Spectrin alpha chain, non-erythrocytic 1
NCBI Official Synonym Full Names
spectrin alpha, non-erythrocytic 1
NCBI Official Symbol
Sptan1
NCBI Official Synonym Symbols
Spna2; Spna-2; 2610027H02Rik
NCBI Protein Information
spectrin alpha chain, non-erythrocytic 1
UniProt Protein Name
Spectrin alpha chain, non-erythrocytic 1
Protein Family
UniProt Gene Name
Sptan1
UniProt Synonym Gene Names
Spna2; Spta2
UniProt Entry Name
SPTN1_MOUSE
Uniprot Description
SPTAN1: a cytoskeletal protein which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Capable to forming dimers which can further associate to tetramers.
Protein type: Cytoskeletal; Adaptor/scaffold; Motility/polarity/chemotaxis
Cellular Component: cortical cytoskeleton; protein complex; intracellular membrane-bound organelle; paranode region of axon; fascia adherens; Z disc; microtubule cytoskeleton; cytoskeleton; membrane; cytoplasm; plasma membrane; myelin sheath; lateral plasma membrane; vesicle
Molecular Function: calmodulin binding; protein binding; syntaxin binding; spectrin binding; protein heterodimerization activity; metal ion binding; protein complex binding; protein N-terminus binding; calcium ion binding; actin binding
Biological Process: actin filament capping; actin cytoskeleton reorganization
Research Articles on Sptan1
Similar Products
Product Notes
The Sptan1 sptan1 (Catalog #AAA841239) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The alpha-Fodrin Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's alpha-Fodrin can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Western blot analysis (0.5-4 ug/ml) and in in Immunohistochemistry (10-20 ug/ml). Researchers should empirically determine the suitability of the Sptan1 sptan1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "alpha-Fodrin, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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