Rabbit anti-Human, Mouse ALDOC Polyclonal Antibody | anti-ALDOC antibody

ALDOC, NT (ALDOC, ALDC, Fructose-bisphosphate aldolase C, Brain-type aldolase) (HRP)

Cat. Num. AAA6272854

• Gene Names: ALDOC; ALDC
• Reactivity: Human, Mouse
• Applications: Western Blot, ELISA
• Purity: Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.
• Synonyms: ALDOC; Polyclonal Antibody; NT (ALDOC; ALDC; Fructose-bisphosphate aldolase C; Brain-type aldolase) (HRP); Brain-type aldolase; anti-ALDOC antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

• Applicable Applications for anti-ALDOC antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:50-100; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: ALDOC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 79-108 amino acids from the N-terminal region of human ALDOC.
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates.

Western Blot (WB)

(ALDOC Antibody (N-term) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the ALDOC antibody detected the ALDOC protein (arrow).)

Western Blot (WB)

(ALDOC Antibody (N-term) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the ALDOC antibody detected the ALDOC protein (arrow).)

Product Categories/Family for anti-ALDOC antibody

Antibodies; Enzymes

References

Martins-de-Souza, D., et al. J Psychiatr Res 44(14):989-991(2010). Sultana, R., et al. Antioxid. Redox Signal. 12(3):327-336(2010). Martins-de-Souza, D., et al. J Psychiatr Res 43(11):978-986(2009). Martins-de-Souza, D., et al. J Neural Transm 116(3):275-289(2009). Martins-de-Souza, D., et al. BMC Psychiatry 9, 17 (2009).

NCBI and Uniprot Product Information

• NCBI GI #: 4885063
• NCBI GeneID: 230
• NCBI Accession #: NP_005156.1
• NCBI GenBank Nucleotide #: NM_005165.2
• UniProt Accession #: P09972; Q3SYL3; Q6FH94; Q6P0L5; B2R5R3
• Molecular Weight: 39,456 Da
• NCBI Official Full Name: fructose-bisphosphate aldolase C
• NCBI Official Synonym Full Names: aldolase C, fructose-bisphosphate
• NCBI Official Symbol: ALDOC
• NCBI Official Synonym Symbols: ALDC
• NCBI Protein Information: fructose-bisphosphate aldolase C; aldolase 3; fructoaldolase C; brain-type aldolase; fructose-1,6-biphosphate triosephosphate lyase
• UniProt Protein Name: Fructose-bisphosphate aldolase C
• Protein Family: Fructose-bisphosphate aldolase
• UniProt Gene Name: ALDOC
• UniProt Synonym Gene Names: ALDC
• UniProt Entry Name: ALDOC_HUMAN

NCBI Description

This gene encodes a member of the class I fructose-biphosphate aldolase gene family. Expressed specifically in the hippocampus and Purkinje cells of the brain, the encoded protein is a glycolytic enzyme that catalyzes the reversible aldol cleavage of fructose-1,6-biphosphate and fructose 1-phosphate to dihydroxyacetone phosphate and either glyceraldehyde-3-phosphate or glyceraldehyde, respectively. [provided by RefSeq, Jul 2008]

Uniprot Description

ALDOC: a member of the class I fructose-biphosphate aldolase gene family. Expressed specifically in the hippocampus and Purkinje cells of the brain, the encoded protein is a glycolytic enzyme that catalyzes the reversible aldol cleavage of fructose-1,6-biphosphate and fructose 1-phosphate to dihydroxyacetone phosphate and either glyceraldehyde-3-phosphate or glyceraldehyde, respectively. [provided by RefSeq, Jul 2008]

Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; Lyase; Carbohydrate Metabolism - fructose and mannose; EC 4.1.2.13

Chromosomal Location of Human Ortholog: 17cen-q12

Cellular Component: cytoskeleton; mitochondrion; axon; cytosol

Molecular Function: protein binding; cytoskeletal protein binding; fructose-bisphosphate aldolase activity

Biological Process: organ regeneration; glycolysis; apoptosis; glucose metabolic process; pathogenesis; response to organic nitrogen; response to organic cyclic substance; protein homotetramerization; gluconeogenesis; fructose 1,6-bisphosphate metabolic process; epithelial cell differentiation; carbohydrate metabolic process; response to hypoxia; protein heterotetramerization; aging; fructose metabolic process