Rabbit ALDH3B2 Polyclonal Antibody | anti-ALDH3B2 antibody

ALDH3B2 Polyclonal Antibody

Cat. Num. AAA3006375

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: ALDH3B2; Polyclonal Antibody; ALDH3B2 Polyclonal Antibody; Aldehyde dehydrogenase family 3 member B2; Aldehyde dehydrogenase 8; ALDH8; anti-ALDH3B2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: ALDH3B2 polyclonal antibody detects endogenous levels of ALDH3B2 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Applicable Applications for anti-ALDH3B2 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:500-1:1000; IHC: 1:50-1:200
• Immunogen: A synthetic peptide corresponding to residues in Human ALDH3B2.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of ALDH3B2 polyclonal antibody at 1:500 dilutionLane1:Hela whole cell lysateLane2:Raw264. 7 whole cell lysateLane3:H9C2 whole cell lysate)

Immunohistochemistry (IHC)

(Immunohistochemistry (IHC) analyzes of ALDH3B2 pAb in paraffin-embedded human liver carcinoma tissue at 1:50,showing cytoplasm and membrane staining. Negative control (the right) Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.)

Related Product Information for anti-ALDH3B2 antibody

ALDH3B2 (aldehyde dehydrogenase 3 family, member B2), also known as ALDH8, is a 385 amino acid protein that belongs to the ALDH family and is involved in the pathway of alcohol metabolism. Expressed in salivary gland tissue, ALDH3B2 functions to catalyze the NADP+-dependent conversion of an aldehyde into an acid. The gene encoding ALDH3B2 maps to human chromosome 11, which houses over 1, 400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11.

NCBI and Uniprot Product Information

• NCBI GI #: 73695879
• UniProt Accession #: P48448
• Molecular Weight: ~ 43kDa
• UniProt Protein Name: Aldehyde dehydrogenase family 3 member B2
• Protein Family: Aldehyde dehydrogenase family
• UniProt Gene Name: ALDH3B2
• UniProt Synonym Gene Names: ALDH8
• UniProt Entry Name: AL3B2_HUMAN

Uniprot Description

ALDH3B2: a member of the aldehyde dehydrogenase family, a group of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The gene of this particular family member is over 10 kb in length. The expression of these transcripts is restricted to the salivary gland among the human tissues examined. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

Protein type: Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - histidine; Oxidoreductase; Xenobiotic Metabolism - metabolism by cytochrome P450; Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.5; Xenobiotic Metabolism - drug metabolism - cytochrome P450

Chromosomal Location of Human Ortholog: 11q13

Molecular Function: aldehyde dehydrogenase (NAD) activity; aldehyde dehydrogenase [NAD(P)+] activity; 3-chloroallyl aldehyde dehydrogenase activity

Biological Process: ethanol catabolic process; alcohol metabolic process; lipid metabolic process