Rabbit ALDH1L1 Polyclonal Antibody | anti-ALDH1L1 antibody

ALDH1L1 Polyclonal Antibody

Cat. Num. AAA3011929

• Gene Names: ALDH1L1; FDH; FTHFD; 10-fTHF; 10-FTHFDH
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: ALDH1L1; Polyclonal Antibody; ALDH1L1 Polyclonal Antibody; Cytosolic 10-formyltetrahydrofolate dehydrogenase; 10-FTHFDH; FDH; Aldehyde dehydrogenase family 1 member L1; FTHFD; anti-ALDH1L1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: ALDH1L1 polyclonal antibody detects endogenous levels of ALDH1L1 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 902

• Applicable Applications for anti-ALDH1L1 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: Recombinant full length Human ALDH1L1.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot analysis of extracts of various cell lines, using ALDH1L1 antibody.)

Related Product Information for anti-ALDH1L1 antibody

The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants.

NCBI and Uniprot Product Information

• NCBI GI #: 59802911
• NCBI GeneID: 10840
• UniProt Accession #: O75891
• Molecular Weight: ~ 120kDa
• NCBI Official Full Name: Cytosolic 10-formyltetrahydrofolate dehydrogenase
• NCBI Official Synonym Full Names: aldehyde dehydrogenase 1 family member L1
• NCBI Official Symbol: ALDH1L1
• NCBI Official Synonym Symbols: FDH; FTHFD; 10-fTHF; 10-FTHFDH
• NCBI Protein Information: cytosolic 10-formyltetrahydrofolate dehydrogenase
• UniProt Protein Name: Cytosolic 10-formyltetrahydrofolate dehydrogenase
• Protein Family: Cytosolic 10-formyltetrahydrofolate dehydrogenase
• UniProt Gene Name: ALDH1L1
• UniProt Synonym Gene Names: FTHFD; 10-FTHFDH; FDH
• UniProt Entry Name: AL1L1_HUMAN

NCBI Description

The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

Uniprot Description

ALDH1L1: 2 isoforms of the human protein are produced by alternative splicing

Protein type: Cofactor and Vitamin Metabolism - one carbon pool by folate; Oxidoreductase; EC 1.5.1.6

Chromosomal Location of Human Ortholog: 3q21.3

Cellular Component: mitochondrion

Molecular Function: methyltransferase activity; aldehyde dehydrogenase (NAD) activity; formyltetrahydrofolate dehydrogenase activity; hydroxymethyl-, formyl- and related transferase activity; catalytic activity

Biological Process: methylation; biosynthetic process; one-carbon compound metabolic process; 10-formyltetrahydrofolate catabolic process