Rabbit AHCYL1 Polyclonal Antibody | anti-AHCYL1 antibody

AHCYL1 Rabbit pAb

Cat. Num. AAA8547032

• Gene Names: AHCYL1; DCAL; IRBIT; PPP1R78; PRO0233; XPVKONA
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity Purified
• Synonyms: AHCYL1; Polyclonal Antibody; AHCYL1 Rabbit pAb; DCAL; IRBIT; PPP1R78; PRO0233; XPVKONA; anti-AHCYL1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purified
• Form/Format: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
• Sequence Length: 483

• Applicable Applications for anti-AHCYL1 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:500-1:2000; IHC: 1:50-1:200
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 31-260 of human AHCYL1 (NP_006612.2).
• Cellular Localization: Cell Membrane, Cytoplasm, Endoplasmic Reticulum, Membrane, Microsome
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Related Product Information for anti-AHCYL1 antibody

Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3-and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITPR1 (PubMed:16793548). When extracellular stimuli induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates of ITPR1 to interact with CFTR and SLC26A6 mediating their synergistic activation by calcium and cAMP that stimulates the epithelial secretion of electrolytes and fluid. Also activates basolateral SLC4A4 isoform 1 to coordinate fluid and HCO3-secretion (PubMed:16769890). Inhibits the effect of STK39 on SLC4A4 and CFTR by recruiting PP1 phosphatase which activates SLC4A4, SLC26A6 and CFTR through dephosphorylation. Mediates the induction of SLC9A3 surface expression produced by Angiotensin-2 (PubMed:20584908). Depending on the cell type, activates SLC9A3 in response to calcium or reverses SLC9A3R2-dependent calcium inhibition (PubMed:18829453). May modulate the polyadenylation state of specific mRNAs, both by controlling the subcellular location of FIP1L1 and by inhibiting PAPOLA activity, in response to a stimulus that alters its phosphorylation state (PubMed:19224921). Acts as a (dATP)-dependent inhibitor of ribonucleotide reductase large subunit RRM1, controlling the endogenous dNTP pool and ensuring normal cell cycle progression (PubMed:25237103). In vitro does not exhibit any S-adenosyl-L-homocysteine hydrolase activity.

NCBI and Uniprot Product Information

• NCBI GI #: 336455095
• NCBI GeneID: 10768
• NCBI Accession #: NP_001229602
• NCBI GenBank Nucleotide #: NP_001229602.1
• UniProt Accession #: O43865
• Molecular Weight: 59kDa
• NCBI Official Full Name: S-adenosylhomocysteine hydrolase-like protein 1 isoform b
• NCBI Official Synonym Full Names: adenosylhomocysteinase like 1
• NCBI Official Symbol: AHCYL1
• NCBI Official Synonym Symbols: DCAL; IRBIT; PPP1R78; PRO0233; XPVKONA
• NCBI Protein Information: S-adenosylhomocysteine hydrolase-like protein 1
• UniProt Protein Name: Putative adenosylhomocysteinase 2
• Protein Family: Adenosylhomocysteinase
• UniProt Gene Name: AHCYL1
• UniProt Synonym Gene Names: DCAL; XPVKONA; AdoHcyase 2; IRBIT
• UniProt Entry Name: SAHH2_HUMAN

NCBI Description

The protein encoded by this gene interacts with inositol 1,4,5-trisphosphate receptor, type 1 and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]