Rabbit anti-Human, Mouse AGA Polyclonal Antibody | anti-AGA antibody

AGA Polyclonal Antibody

Cat. Num. AAA2565002

• Gene Names: AGA; GA; AGU; ASRG
• Reactivity: Human, Mouse
• Applications: Immunofluorescence
• Purity: Affinity purification
• Synonyms: AGA; Polyclonal Antibody; AGA Polyclonal Antibody; AGU; ASRG; GA; anti-AGA antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purification
• Form/Format: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: 1mg/mL (varies by lot)

• Applicable Applications for anti-AGA antibody: Immunofluorescence (IF)
• Application Notes: IF: 1:50-1:100
• Immunogen: Recombinant fusion protein of human AGA (NP_0000182)
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Immunofluorescence (IF)

(Immunofluorescence analysis of HeLa cells using AGA Polyclonal Antibody )

Related Product Information for anti-AGA antibody

This gene encodes a member of the N-terminal nucleophile (Ntn) hydrolase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta chains that comprise the mature enzyme. This enzyme is involved in the catabolism of N-linked oligosaccharides of glycoproteins. It cleaves asparagine from N-acetylglucosamines as one of the final steps in the lysosomal breakdown of glycoproteins. Mutations in this gene are associated with the lysosomal storage disease aspartylglycosaminuria that results in progressive neurodegeneration. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is subject to proteolytic processing.

Product Categories/Family for anti-AGA antibody

Polyclonal Antibody

NCBI and Uniprot Product Information

• NCBI GI #: 49456391
• NCBI GeneID: 175
• UniProt Accession #: P20933; Q4W5Q2; Q6FHN6; Q9UCK6; Q9UCK7; Q9UCK8; B2R7H2; D3DP47
• Molecular Weight: 37,208 Da
• NCBI Official Full Name: AGA, partial
• NCBI Official Synonym Full Names: aspartylglucosaminidase
• NCBI Official Symbol: AGA
• NCBI Official Synonym Symbols: GA; AGU; ASRG
• NCBI Protein Information: N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase; glycosylasparaginase; aspartylglucosylamine deaspartylase; N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase
• UniProt Protein Name: N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
• Protein Family: Agaricus bisporus lectin
• UniProt Gene Name: AGA
• UniProt Entry Name: ASPG_HUMAN

NCBI Description

Aspartylglucosaminidase is involved in the catabolism of N-linked oligosaccharides of glycoproteins. It cleaves asparagine from N-acetylglucosamines as one of the final steps in the lysosomal breakdown of glycoproteins. The lysosomal storage disease aspartylglycosaminuria is caused by a deficiency in the AGA enzyme. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Jan 2010]

Uniprot Description

AGA: a catabolic enzyme, aspartylglucosaminidase is involved in the catabolism of N-linked oligosaccharides of glycoproteins. It cleaves asparagine from N-acetylglucosamines as one of the final steps in the lysosomal breakdown of glycoproteins. The lysosomal storage disease aspartylglycosaminuria is caused by a deficiency in the AGA enzyme.

Protein type: Glycan Metabolism - other glycan degradation; EC 3.5.1.26; Hydrolase

Chromosomal Location of Human Ortholog: 4q34.3

Cellular Component: endoplasmic reticulum; lysosome

Molecular Function: peptidase activity; protein self-association; N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity

Biological Process: protein deglycosylation; protein maturation; proteolysis

Disease: Aspartylglucosaminuria