Western Blot (WB)
(Western BlotPositive WB detected in:Mouse brain tissue,Human placenta tissueAll lanes: ADRB1 antibody at 3ug/mlSecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 52 kDaObserved band size: 52,48 kDa)
Rabbit anti-Human, Mouse ADRB1 Polyclonal Antibody | anti-ADRB1 antibody
ADRB1 Antibody
IHC: 1: 20-1: 200
IF: 1: 50-1: 200
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Western Blot (WB)
(Western BlotPositive WB detected in:Mouse brain tissue,Human placenta tissueAll lanes: ADRB1 antibody at 3ug/mlSecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 52 kDaObserved band size: 52,48 kDa)
Western Blot (WB)
(Western BlotPositive WB detected in:Mouse brain tissue,Human placenta tissueAll lanes: ADRB1 antibody at 3ug/mlSecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 52 kDaObserved band size: 52,48 kDa)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human heart tissue using MBS7047624 at dilution of 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human heart tissue using MBS7047624 at dilution of 1:100)
Immunohistochemistry (IHC)
(Immunofluorescent analysis of HepG2 cells using MBS7047624 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))
Immunohistochemistry (IHC)
(Immunofluorescent analysis of HepG2 cells using MBS7047624 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))
NCBI and Uniprot Product Information
NCBI Description
The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq, Jul 2008]
Uniprot Description
ADRB1: a GPCR-coupled 7 transmembrane receptor that binds epinephrine and norepinephrine with approximately equal affinity. Mediates the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Interacts with PIST and PSD-95. Localized at the plasma membrane and in the Golgi upon PIST overexpression. Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 10q25.3
Cellular Component: early endosome; integral to plasma membrane; plasma membrane
Molecular Function: alpha-2A adrenergic receptor binding; beta-adrenergic receptor activity; epinephrine binding; norepinephrine binding; PDZ domain binding; protein binding; protein heterodimerization activity; Ras guanyl-nucleotide exchange factor activity; receptor signaling protein activity
Biological Process: adenylate cyclase activation; cell-cell signaling; norepinephrine-epinephrine vasodilation involved in regulation of systemic arterial blood pressure; positive regulation of cAMP biosynthetic process; positive regulation of GTPase activity; positive regulation of heart rate by epinephrine-norepinephrine; thermoregulation
Disease: Resting Heart Rate, Variation In
Research Articles on ADRB1
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Product Notes
The ADRB1 adrb1 (Catalog #AAA7047624) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ADRB1 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's ADRB1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). WB: 1: 500-1: 5000 IHC: 1: 20-1: 200 IF: 1: 50-1: 200. Researchers should empirically determine the suitability of the ADRB1 adrb1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ADRB1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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