Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human tonsil cancer tissue using at dilution 1/25.)
Rabbit anti-Human ADRB1 Polyclonal Antibody | anti-ADRB1 antibody
ADRB1 Antibody
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human tonsil cancer tissue using at dilution 1/25.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human tonsil cancer tissue using at dilution 1/25.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue using at dilution 1/25.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue using at dilution 1/25.)
NCBI and Uniprot Product Information
NCBI Description
The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq, Jul 2008]
Uniprot Description
ADRB1: a GPCR-coupled 7 transmembrane receptor that binds epinephrine and norepinephrine with approximately equal affinity. Mediates the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Interacts with PIST and PSD-95. Localized at the plasma membrane and in the Golgi upon PIST overexpression. Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase.
Protein type: Receptor, GPCR; Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 10q25.3
Cellular Component: integral to plasma membrane; early endosome; plasma membrane; nucleus
Molecular Function: protein binding; protein heterodimerization activity; receptor signaling protein activity; dopamine binding; drug binding; norepinephrine binding; epinephrine binding; alpha-2A adrenergic receptor binding; beta-adrenergic receptor activity; Ras guanyl-nucleotide exchange factor activity; beta1-adrenergic receptor activity; PDZ domain binding
Biological Process: fear response; diet induced thermogenesis; glycogen catabolic process; negative regulation of multicellular organism growth; wound healing; apoptosis; positive regulation of apoptosis; adenylate cyclase activation; lipid homeostasis; positive regulation of systemic arterial blood pressure; regulation of calcium ion transport; sensory perception of pain; positive regulation of saliva secretion; memory; Rho protein signal transduction; regulation of inhibitory postsynaptic membrane potential; positive regulation of the force of heart contraction by norepinephrine; protein localization in organelle; heat generation; negative regulation of smooth muscle contraction; positive regulation of cAMP biosynthetic process; brown fat cell differentiation; response to cold; positive regulation of heart rate by epinephrine-norepinephrine; aging; norepinephrine-epinephrine vasodilation involved in regulation of systemic arterial blood pressure
Disease: Resting Heart Rate, Variation In
Research Articles on ADRB1
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Product Notes
The ADRB1 adrb1 (Catalog #AAA9414159) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ADRB1 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ADRB1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). Immunohistochemistry: 1:25-1:100. Researchers should empirically determine the suitability of the ADRB1 adrb1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ADRB1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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