Rabbit ADH1B Polyclonal Antibody | anti-ADH1B antibody

ADH1B Antibody

Cat. Num. AAA9611560

• Gene Names: ADH1B; ADH2; HEL-S-117
• Reactivity: Human; Mouse; Rat
• Applications: Western Blot
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: ADH1B; Polyclonal Antibody; ADH1B Antibody; ADH beta subunit; ADH1B_HUMAN; ADH2; Alcohol dehydrogenase 1B; alcohol dehydrogenase 2 (class I); beta polypeptide; Alcohol dehydrogenase 2; Alcohol dehydrogenase subunit beta; Aldehyde reductase; DKFZp686C06125; OTTHUMP00000220192;; anti-ADH1B antibody

• Host: Rabbit
• Reactivity: Human; Mouse; Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: ADH1B Antibody detects endogenous levels of ADH1B.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid
• Concentration: 1mg/ml (varies by lot)
• Sequence Length: 375

• Applicable Applications for anti-ADH1B antibody: Western Blot (WB)
• Application Notes: WB 1:500-1:2000
• Immunogen: A synthesized peptide derived from human ADH1B.
• Fragment: Fab fragment
• Conjugation: Unconjugated
• Storage Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C. Stable for 12 months from date of receipt.
• Preparation and Storage: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 degree C. Stable for 12 months from date of receipt.

Related Product Information for anti-ADH1B antibody

There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family.

NCBI and Uniprot Product Information

• NCBI GI #: 113394
• NCBI GeneID: 125
• UniProt Accession #: P00325
• Molecular Weight: Observed Mol.Wt.: 40 kDa. Predicted Mol.Wt.: 40kDa.
• NCBI Official Full Name: All-trans-retinol dehydrogenase
• NCBI Official Synonym Full Names: alcohol dehydrogenase 1B (class I), beta polypeptide
• NCBI Official Symbol: ADH1B
• NCBI Official Synonym Symbols: ADH2; HEL-S-117
• NCBI Protein Information: all-trans-retinol dehydrogenase [NAD(+)] ADH1B
• UniProt Protein Name: Alcohol dehydrogenase 1B
• UniProt Gene Name: ADH1B
• UniProt Synonym Gene Names: ADH2
• UniProt Entry Name: ADH1B_HUMAN

NCBI Description

The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Uniprot Description

ADH1B: Dimer of identical or non-identical chains of three types; alpha, beta and gamma. Belongs to the zinc-containing alcohol dehydrogenase family.

Protein type: Lipid Metabolism - fatty acid; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Xenobiotic Metabolism - metabolism by cytochrome P450; EC 1.1.1.1; Oxidoreductase; Amino Acid Metabolism - tyrosine; Cofactor and Vitamin Metabolism - retinol; Xenobiotic Metabolism - drug metabolism - cytochrome P450

Chromosomal Location of Human Ortholog: 4q23

Cellular Component: cytosol

Molecular Function: zinc ion binding; alcohol dehydrogenase activity, zinc-dependent

Biological Process: xenobiotic metabolic process; ethanol oxidation

Disease: Alcohol Dependence