Chicken anti-Human Adenylate Cyclase 6a Polyclonal Antibody | anti-Adcy5 antibody

Adenylate Cyclase 6a (ADCY6a)

Cat. Num. AAA616539

• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Adenylate Cyclase 6a; Polyclonal Antibody; Adenylate Cyclase 6a (ADCY6a); Anti -Adenylate Cyclase 6a (ADCY6a); anti-Adcy5 antibody

• Host: Chicken
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgY
• Specificity: Recognizes human ADCY6a.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.

• Applicable Applications for anti-Adcy5 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: Western Blot: 1:1000-1:2000
• Immunogen: Synthetic peptide corresponding to aa1-121
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Western Blot (WB)

(Western Blot: E coli-derived fusion protein as test antigen. Affi-anti-ATP7A IgY dilution: 1:2000, Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signal development.)

Product Categories/Family for anti-Adcy5 antibody

Antibodies; Abs to Enzymes; Cyclase

NCBI and Uniprot Product Information

• NCBI GI #: 12018268
• NCBI GeneID: 64532
• NCBI Accession #: NP_072122.1
• NCBI GenBank Nucleotide #: NM_022600.1
• UniProt Accession #: Q04400
• Molecular Weight: 139,179 Da
• NCBI Official Full Name: adenylate cyclase type 5
• NCBI Official Synonym Full Names: adenylate cyclase 5
• NCBI Official Symbol: Adcy5
• NCBI Protein Information: adenylate cyclase type 5; adenylyl cyclase 5; adenylyl cyclase type V; adenylate cyclase type V; ATP pyrophosphate-lyase 5
• UniProt Protein Name: Adenylate cyclase type 5
• Protein Family: Adenylate cyclase
• UniProt Gene Name: Adcy5
• UniProt Entry Name: ADCY5_RAT

NCBI Description

enzyme that catalyzes the formation of the secondary messenger cyclic adenosine monophosphate [RGD, Feb 2006]

Uniprot Description

Function: This is a membrane-bound, calcium-inhibitable adenylyl cyclase.

Catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate.

Cofactor: Binds 2 magnesium ions per subunit

By similarity.

Enzyme regulation: Inhibition by calcium in the submicromolar concentration range. Phosphorylation by RAF1 results in its activation

By similarity.

Subunit structure: Part of a complex containing AKAP5, ADCY6, PDE4C and PKD2

By similarity. Interacts with RAF1

By similarity.

Subcellular location: Membrane; Multi-pass membrane protein. Cell projection › cilium

By similarity.

Post-translational modification: Phosphorylated by RAF1

By similarity.

Sequence similarities: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.Contains 2 guanylate cyclase domains.