Rabbit ADAMTS4 Polyclonal Antibody | anti-ADAMTS4 antibody

Rabbit Polyclonal to Human ADAMTS4

Cat. Num. AAA244980

• Gene Names: ADAMTS4; ADMP-1; ADAMTS-2; ADAMTS-4
• Reactivity: Bat, Gibbon, Bovine, Dog, Guinea pig, Hamster, Horse, Human, Monkey, Mouse, Orangutan; Predicted Reactivity: Rat, Pig (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: ADAMTS4; Polyclonal Antibody; Rabbit Polyclonal to Human ADAMTS4; Anti-ADAMTS4 Antibody (Disintegrin-like Domain) IHC-plus; ADAMTS-2; ADAMTS-4; ADAM-TS 4; ADAM-TS4; ADMP-1; Aggrecanase-1; KIAA0688; Human ADAMTS4; anti-ADAMTS4 antibody

• Host: Rabbit
• Reactivity: Bat, Gibbon, Bovine, Dog, Guinea pig, Hamster, Horse, Human, Monkey, Mouse, Orangutan; Predicted Reactivity: Rat, Pig (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human ADAMTS4. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 837

• Applicable Applications for anti-ADAMTS4 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (2 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 15 amino acid peptide from Disintegrin-like domain of human ADAMTS4. Percent identity with other species by BLAST analysis: Human, Orangutan, Gibbon, Monkey, Marmoset, Mouse, Hamster, Elephant, Panda, Dog, Bat, Bovine, Horse.
• Immunogen Type: Synthetic peptide
• Immunogen: ADAMTS4 antibody was raised against synthetic 15 amino acid peptide from Disintegrin-like domain of human ADAMTS4. Percent identity with other species by BLAST analysis: Human, Orangutan, Gibbon, Monkey, Marmoset, Mouse, Hamster, Elephant, Panda, Dog, Bat, Bovine, Horse, Guinea pig (100%); Rat, Pig, Opossum (93%).
• Antigen Modification: Disintegrin-like Domain
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-ADAMTS4 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-ADAMTS4 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-ADAMTS4 antibody IHC of human cartilage. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-ADAMTS4 antibody

ADAMTS4, also known as aggrecanase-1, is a Metallopeptidase M12B type protease that is responsible for degradation of the articular cartilage protein aggrecan and the brain extracellular matrix proteoglycan brevican. The ADAMTS4 protein contains a signal sequence, a propeptide domain, a catalytic domain, a disintegrin-like motif, and a C-terminal domain with a thrombospondin (TSP) type 1 motif.

Product Categories/Family for anti-ADAMTS4 antibody

Family: Protease; Subfamily: Metallopeptidase M12B

NCBI and Uniprot Product Information

• NCBI GI #: 157427675
• NCBI GeneID: 9507
• NCBI Accession #: NP_005090.3
• NCBI GenBank Nucleotide #: NM_005099.4
• UniProt Accession #: O75173; Q2HYD0; Q5VTW2; Q6P4Q8; Q6UWA8; Q9UN83
• Molecular Weight: 83,030 Da
• NCBI Official Full Name: A disintegrin and metalloproteinase with thrombospondin motifs 4 preproprotein
• NCBI Official Synonym Full Names: ADAM metallopeptidase with thrombospondin type 1 motif, 4
• NCBI Official Symbol: ADAMTS4
• NCBI Official Synonym Symbols: ADMP-1; ADAMTS-2; ADAMTS-4
• NCBI Protein Information: A disintegrin and metalloproteinase with thrombospondin motifs 4; ADAM-TS4; ADAM-TS 4; aggrecanase-1; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4
• UniProt Protein Name: A disintegrin and metalloproteinase with thrombospondin motifs 4
• Protein Family: A disintegrin and metalloproteinase with thrombospondin motifs
• UniProt Gene Name: ADAMTS4
• UniProt Synonym Gene Names: KIAA0688; ADAM-TS 4; ADAM-TS4; ADAMTS-4
• UniProt Entry Name: ATS4_HUMAN

NCBI Description

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma. [provided by RefSeq, Jul 2008]

Uniprot Description

ADAMTS4: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.

Protein type: Secreted, signal peptide; Protease; Secreted; Motility/polarity/chemotaxis; EC 3.4.24.82

Chromosomal Location of Human Ortholog: 1q21-q23

Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; extracellular region

Molecular Function: peptidase activity; protein binding; protease binding; zinc ion binding; metallopeptidase activity; metalloendopeptidase activity

Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; defense response to bacterium; proteolysis; skeletal development