Rabbit anti-Human, Mouse ADAMTS4 Polyclonal Antibody | anti-ADAMTS4 antibody

ADAMTS4, CT (ADMP-1, Aggrecanase-1, A Disintegrin And Metalloproteinase With Thrombospondin Motifs 4, ADAMTS-4, ADAM-TS 4, ADAM-TS4, KIAA0688, UNQ769/PRO1563)

Cat. Num. AAA627201

• Gene Names: ADAMTS4; ADMP-1; ADAMTS-2; ADAMTS-4; KIAA0688
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography
• Synonyms: ADAMTS4; Polyclonal Antibody; CT (ADMP-1; Aggrecanase-1; A Disintegrin And Metalloproteinase With Thrombospondin Motifs 4; ADAMTS-4; ADAM-TS 4; ADAM-TS4; KIAA0688; UNQ769/PRO1563); Anti -ADAMTS4; anti-ADAMTS4 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human ADAMTS4 at ~90kD.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography
• Form/Format: Supplied as a liquid in PBS, 0.09% sodium azide.

• Applicable Applications for anti-ADAMTS4 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: ELISA: 1:1000; Western Blot: 1:50-1:100
• Immunogen: KLH-conjugated synthetic peptide corresponding to a portion of amino acids within the range aa713-743 near the C-terminal region of human ADAMTS4
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of anti-ADAMTS4 Antibody (C-term) in mouse cerebellum tissue lysates (35ug/lane). ADAMTS4 (arrow) was detected using the purified Pab.)

Related Product Information for anti-ADAMTS4 antibody

ADAMTS4 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.

Product Categories/Family for anti-ADAMTS4 antibody

Antibodies; Abs to Matrix Metalloproteinases

NCBI and Uniprot Product Information

• NCBI GI #: 157427675
• NCBI GeneID: 9507
• NCBI Accession #: NP_005090.3
• NCBI GenBank Nucleotide #: NM_005099.4
• UniProt Accession #: O75173; Q5VTW2; Q6P4Q8; Q6UWA8; Q9UN83; Q2HYD0
• Molecular Weight: 90,197 Da
• NCBI Official Full Name: A disintegrin and metalloproteinase with thrombospondin motifs 4 preproprotein
• NCBI Official Synonym Full Names: ADAM metallopeptidase with thrombospondin type 1 motif, 4
• NCBI Official Symbol: ADAMTS4
• NCBI Official Synonym Symbols: ADMP-1; ADAMTS-2; ADAMTS-4; KIAA0688
• NCBI Protein Information: A disintegrin and metalloproteinase with thrombospondin motifs 4; ADAM-TS4; ADAM-TS 4; aggrecanase-1; OTTHUMP00000032249; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4
• UniProt Protein Name: A disintegrin and metalloproteinase with thrombospondin motifs 4
• Protein Family: A disintegrin and metalloproteinase with thrombospondin motifs
• UniProt Gene Name: ADAMTS4
• UniProt Synonym Gene Names: KIAA0688
• UniProt Entry Name: ATS4_HUMAN

NCBI Description

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma. [provided by RefSeq]

Uniprot Description

ADAMTS4: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.

Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted; EC 3.4.24.82; Protease

Chromosomal Location of Human Ortholog: 1q21-q23

Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; extracellular region

Molecular Function: peptidase activity; protein binding; protease binding; metallopeptidase activity; zinc ion binding; metalloendopeptidase activity

Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; defense response to bacterium; proteolysis; skeletal development