Western Blot (WB)
(Anti-ADAMTS2 antibody, MBS175567, Western blottingLane 1: Rat Brain Tissue LysateLane 2: Rat Heart Tissue Lysate )
Rabbit ADAMTS2 Polyclonal Antibody | anti-ADAMTS2 antibody
Anti-ADAMTS2 antibody
Western Blot (WB)
(Anti-ADAMTS2 antibody, MBS175567, Western blottingLane 1: Rat Brain Tissue LysateLane 2: Rat Heart Tissue Lysate )
Western Blot (WB)
(Anti-ADAMTS2 antibody, MBS175567, Western blottingLane 1: Rat Brain Tissue LysateLane 2: Rat Heart Tissue Lysate )
Immunohistochemistry (IHC)
(Anti-ADAMTS2 antibody, MBS175567, IHC(P)IHC(P): Rat Cardiac Muscle Tissue )
Immunohistochemistry (IHC)
(Anti-ADAMTS2 antibody, MBS175567, IHC(P)IHC(P): Rat Cardiac Muscle Tissue )
Immunohistochemistry (IHC)
(Anti-ADAMTS2 antibody, MBS175567, IHC(F)IHC(F): Rat Cardiac Muscle Tissue )
Immunohistochemistry (IHC)
(Anti-ADAMTS2 antibody, MBS175567, IHC(F)IHC(F): Rat Cardiac Muscle Tissue )
Immunohistochemistry (IHC)
(Anti-ADAMTS2 antibody, MBS175567, IHC(F)IHC(F): Rat Trachea Tissue )
Immunohistochemistry (IHC)
(Anti-ADAMTS2 antibody, MBS175567, IHC(F)IHC(F): Rat Trachea Tissue )
Background: ADAMTS2, A disintegrin and metalloproteinase with thrombospondin motifs 2, also known as procollagen I N-proteinase(PC I-NP), is an enzyme that in humans is encoded by the ADAMTS2 gene. The ADAMTS2 gene contains 22 exons. The human ADAMTS2 gene is mapped to chromosome 5q23-q24 by analysis of somatic cell hybrids. ADAMTS2 is responsible for processing several types of procollagen proteins. Procollagens are the precursors of collagens, the proteins that add strength and support to many body tissues. Specifically, this enzyme clips a short chain of amino acids off one end of the procollagen. This clipping step is necessary for collagen molecules to function normally and assemble into fibrils outside cells.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene excises the N-propeptide of type I, type II and type V procollagens. Mutations in this gene cause Ehlers-Danlos syndrome type VIIC, a recessively inherited connective-tissue disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
Uniprot Description
ADAMTS2: Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis. Defects in ADAMTS2 are the cause of Ehlers-Danlos syndrome type 7C (EDS7C). EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS7C is marked by extremely fragile tissues, hyperextensible skin and easy bruising. Facial skin contains numerous folds, as in the cutis laxa syndrome. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Extracellular matrix; EC 3.4.24.14; Secreted; Secreted, signal peptide; Protease
Chromosomal Location of Human Ortholog: 5qter
Cellular Component: proteinaceous extracellular matrix; extracellular region
Molecular Function: metallopeptidase activity; zinc ion binding; metalloendopeptidase activity
Biological Process: skin development; collagen catabolic process; extracellular matrix organization and biogenesis; collagen fibril organization; spermatogenesis; protein processing; proteolysis; lung development
Disease: Ehlers-danlos Syndrome, Type Vii, Autosomal Recessive
Research Articles on ADAMTS2
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Product Notes
The ADAMTS2 adamts2 (Catalog #AAA175567) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-ADAMTS2 antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's ADAMTS2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunohistochemistry (IHC) Formalin. Researchers should empirically determine the suitability of the ADAMTS2 adamts2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ADAMTS2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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