Rabbit ADAM19 Polyclonal Antibody | anti-ADAM19 antibody

ADAM19 Polyclonal Antibody

Cat. Num. AAA9130771

• Gene Names: ADAM19; MLTNB; FKSG34; MADDAM
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Affinity Purification
• Synonyms: ADAM19; Polyclonal Antibody; ADAM19 Polyclonal Antibody; FKSG34; MADDAM; MLTNB; anti-ADAM19 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Sequence Length: 955

• Applicable Applications for anti-ADAM19 antibody: Western Blot (WB)
• Application Notes: WB: 1:1000 - 1:2000
• Immunogen: Recombinant protein of human ADAM19
• Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using ADAM19 antibody at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 90s.)

Related Product Information for anti-ADAM19 antibody

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has been demonstrated to be an active metalloproteinase, which may be involved in normal physiological processes such as cell migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. It is proposed to play a role in pathological processes, such as cancer, inflammatory diseases, renal diseases, and Alzheimer's disease.

Product Categories/Family for anti-ADAM19 antibody

Primary antibody

NCBI and Uniprot Product Information

• NCBI GI #: 302393821
• NCBI GeneID: 8728
• UniProt Accession #: Q9H013; Q9BZL5; Q9UHP2
• Molecular Weight: 105kDa
• NCBI Official Full Name: Disintegrin and metalloproteinase domain-containing protein 19
• NCBI Official Synonym Full Names: ADAM metallopeptidase domain 19
• NCBI Official Symbol: ADAM19
• NCBI Official Synonym Symbols: MLTNB; FKSG34; MADDAM
• NCBI Protein Information: disintegrin and metalloproteinase domain-containing protein 19
• UniProt Protein Name: Disintegrin and metalloproteinase domain-containing protein 19
• Protein Family: Disintegrin and metalloproteinase domain-containing protein
• UniProt Gene Name: ADAM19
• UniProt Synonym Gene Names: MLTNB; ADAM 19; MADDAM

NCBI Description

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has been demonstrated to be an active metalloproteinase, which may be involved in normal physiological processes such as cell migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. It is proposed to play a role in pathological processes, such as cancer, inflammatory diseases, renal diseases, and Alzheimer's disease. [provided by RefSeq, May 2013]

Uniprot Description

ADAM19: Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.24.-; Membrane protein, integral; Motility/polarity/chemotaxis; Protease

Chromosomal Location of Human Ortholog: 5q33.3