Rabbit anti-Mouse Acvr1c Polyclonal Antibody | anti-Acvr1c antibody

Acvr1c, CT (Acvr1c, Alk7, Activin receptor type-1C, Activin receptor type IC, Activin receptor-like kinase 7) (FITC)

Cat. Num. AAA6271412

• Gene Names: Acvr1c; ALK7; Alk-7; ACVRLK7; C230097P10
• Reactivity: Mouse
• Applications: Western Blot
• Purity: Purified by Protein A and Peptide Affinity Chromatography.
• Synonyms: Acvr1c; Polyclonal Antibody; CT (Acvr1c; Alk7; Activin receptor type-1C; Activin receptor type IC; Activin receptor-like kinase 7) (FITC); Activin receptor-like kinase 7; anti-Acvr1c antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes mouse Acvr1c
• Purity/Purification: Purified by Protein A and Peptide Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-Acvr1c antibody: Western Blot (WB), FLISA
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 341-368 in the C-terminal region of mouse Acvr1c. Species sequence homology: human, rat
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in mouse heart tissue lysates (35ug/lane) usingMBS6004401. This demonstrates that MBS6004401 detected the Acvr1c protein (arrow).)

Related Product Information for anti-Acvr1c antibody

Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.

Product Categories/Family for anti-Acvr1c antibody

Antibodies; Protein Kinases

References

1. Andersson, O., et al. Proc. Natl. Acad. Sci. U.S.A. 105(20):7252-7256(2008). 2. Bertolino, P., et al. Proc. Natl. Acad. Sci. U.S.A. 105(20):7246-7251(2008). 3. Liguori, G.L., et al. Dev. Biol. 315(2):280-289(2008). 4. Kurrasch, D.M., et al. J. Neurosci. 27(50):13624-13634(2007). 5. Kogame, M., et al. J. Med. Invest. 53 (3-4), 238-245 (2006).

NCBI and Uniprot Product Information

• NCBI GI #: 161333831
• NCBI GeneID: 269275
• NCBI Accession #: NP_001104500.1
• NCBI GenBank Nucleotide #: NM_001111030.1
• UniProt Accession #: Q8K348; A2AJR4
• Molecular Weight: 54,700 Da
• NCBI Official Full Name: activin receptor type-1C isoform 1
• NCBI Official Synonym Full Names: activin A receptor, type IC
• NCBI Official Symbol: Acvr1c
• NCBI Official Synonym Symbols: ALK7; Alk-7; ACVRLK7; C230097P10
• NCBI Protein Information: activin receptor type-1C
• UniProt Protein Name: Activin receptor type-1C
• Protein Family: Activin receptor
• UniProt Gene Name: Acvr1c
• UniProt Synonym Gene Names: ACTR-IC; ALK-7
• UniProt Entry Name: ACV1C_MOUSE

Uniprot Description

ALK7: Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Kinase, protein; Protein kinase, Ser/Thr (receptor); EC 2.7.11.30; Protein kinase, TKL; TKL group; STKR family; Type1 subfamily

Cellular Component: activin receptor complex; cell surface; cytoplasm; integral to membrane; membrane; plasma membrane

Molecular Function: activin binding; activin receptor activity, type I; ATP binding; growth factor binding; kinase activity; metal ion binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity; SMAD binding; transferase activity; transmembrane receptor protein serine/threonine kinase activity

Biological Process: activin receptor signaling pathway; apoptosis; apoptotic nuclear changes; cell differentiation; determination of left/right symmetry; in utero embryonic development; negative regulation of insulin secretion; phosphorylation; positive regulation of apoptosis; positive regulation of caspase activity; protein amino acid phosphorylation; regulation of apoptosis; response to dietary excess; response to glucose stimulus; response to insulin stimulus; sequestering of lipid; transforming growth factor beta receptor complex assembly; transmembrane receptor protein serine/threonine kinase signaling pathway; trophectodermal cell proliferation