Goat anti-Human Activin Receptor Type IIA Polyclonal Antibody | anti-Acvr2a antibody
Activin Receptor Type IIA (RIIA)
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Dilution: Neutralization: ~1-3ug/ml will block 50% of the binding of 30ng/ml recombinant human Activin A to immobilized recombinant human Act RIIA/Fc Chimera (100ul of a 0.5ug/ml solution was coated in each well) in a functional ELISA assay.
Direct ELISA: 0.5-1.0ug/ml. The detection limit is ~0.3ng/well.
Western Blot: 0.1-0.2ug/ml. The detection limit is ~5ng/lane and 25ng/lane under non-reducing and reducing conditions, respectively.
Immunohistochemistry (Paraffin): 15ug/ml for 5-15um thick sections. For detection of labeling, the ABC technique using chromogenic substrates is recommended.
NCBI and Uniprot Product Information
NCBI Description
acts as a receptor for activin A and inhibin A [RGD]
Uniprot Description
ACVR2A: a tyrosine-kinase like receptor kinase of the STKR family. The holoreceptor receptor is a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Each is composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic kinase domain. Type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptor kinases are apparently constitutively active.
Protein type: Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; Motility/polarity/chemotaxis; Kinase, protein; EC 2.7.11.30; Membrane protein, integral; TKL group; STKR family; Type2 subfamily
Cellular Component: cell surface; cytoplasm; integral to membrane; activin receptor complex; receptor complex
Molecular Function: protein serine/threonine kinase activity; activin receptor activity; protein self-association; growth factor binding; metal ion binding; activin binding; coreceptor activity; activin receptor activity, type II; transmembrane receptor protein serine/threonine kinase activity; ATP binding; receptor signaling protein serine/threonine kinase activity; PDZ domain binding
Biological Process: positive regulation of erythrocyte differentiation; embryonic skeletal development; male gonad development; regulation of BMP signaling pathway; activin receptor signaling pathway; regulation of signal transduction; Sertoli cell proliferation; gastrulation with mouth forming second; positive regulation of bone mineralization; protein amino acid phosphorylation; response to organic substance; anterior/posterior pattern formation; BMP signaling pathway; positive regulation of osteoblast differentiation; positive regulation of activin receptor signaling pathway; mesoderm development; spermatogenesis; positive regulation of protein amino acid phosphorylation; positive regulation of follicle-stimulating hormone secretion; regulation of nitric-oxide synthase activity; sperm ejaculation; determination of left/right symmetry; penile erection
Research Articles on Acvr2a
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Product Notes
The Acvr2a acvr2a (Catalog #AAA621590) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Activin Receptor Type IIA (RIIA) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Activin Receptor Type IIA can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Neutralization. Suitable for use in Neutralization, ELISA, Western Blot and Immunohistochemistry. Dilution: Neutralization: ~1-3ug/ml will block 50% of the binding of 30ng/ml recombinant human Activin A to immobilized recombinant human Act RIIA/Fc Chimera (100ul of a 0.5ug/ml solution was coated in each well) in a functional ELISA assay. Direct ELISA: 0.5-1.0ug/ml. The detection limit is ~0.3ng/well. Western Blot: 0.1-0.2ug/ml. The detection limit is ~5ng/lane and 25ng/lane under non-reducing and reducing conditions, respectively. Immunohistochemistry (Paraffin): 15ug/ml for 5-15um thick sections. For detection of labeling, the ABC technique using chromogenic substrates is recommended. Researchers should empirically determine the suitability of the Acvr2a acvr2a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Activin Receptor Type IIA, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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