Rabbit ACSL6 Polyclonal Antibody | anti-ACSL6 antibody

ACSL6 (D531) Polyclonal Antibody

Cat. Num. AAA3003460

• Gene Names: ACSL6; ACS2; FACL6; LACS2; LACS5; LACS 6
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: ACSL6; Polyclonal Antibody; ACSL6 (D531) Polyclonal Antibody; Long-chain-fatty-acid--CoA ligase 6; Long-chain acyl-CoA synthetase 6; LACS 6; ACS2; FACL6; KIAA0837; LACS5; anti-ACSL6 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: ACSL6 (D531) polyclonal antibody detects endogenous levels of ACSL6 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 722

• Applicable Applications for anti-ACSL6 antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:200
• Immunogen: Synthetic peptide, corresponding to amino acids 500-550 of Human ACSL6.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry (IHC) analyzes of ACSL6 (D531) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.)

Related Product Information for anti-ACSL6 antibody

Acyl-CoA synthetases, also known as long-chain fatty-acid CoA synthases (FACL) or Palmitoyl-CoA ligases, include ACSL1-6, which are all single-pass membrane proteins localizing to the mitochondrion, microsome or peroxisome.ACSL proteins are important for synthesis of cellular lipids and for beta-oxidation degradation. Specifically, ACSL proteins catalyze the activation of long-chain fatty acids to acyl-CoAs, which can be metabolized to form CO2, triacylglycerol (TAG), phospholipids (PL) and cholesteryl esters (CE). ACSL6 has been shown to be an ETV6 fusion partner gene in a recurrent t(5;12) (q31;p13) translocation in a patient with refractory anemia with excess blasts (RAEB) with basophilia, a patient with acute myelogenous leukemia (AML) with eosinophilia, and a patient with acute eosinophilic leukemia (AEL).

NCBI and Uniprot Product Information

• NCBI GI #: 57165412
• NCBI GeneID: 23305
• NCBI Accession #: NP_001009185.1
• NCBI GenBank Nucleotide #: NP_001009185.1
• UniProt Accession #: Q9UKU0
• Molecular Weight: ~ 78kDa
• NCBI Official Full Name: long-chain-fatty-acid--CoA ligase 6 isoform b
• NCBI Official Synonym Full Names: acyl-CoA synthetase long chain family member 6
• NCBI Official Symbol: ACSL6
• NCBI Official Synonym Symbols: ACS2; FACL6; LACS2; LACS5; LACS 6
• NCBI Protein Information: long-chain-fatty-acid--CoA ligase 6
• UniProt Protein Name: Long-chain-fatty-acid--CoA ligase 6
• Protein Family: Long-chain-fatty-acid--CoA ligase
• UniProt Gene Name: ACSL6
• UniProt Synonym Gene Names: ACS2; FACL6; KIAA0837; LACS5; LACS 6
• UniProt Entry Name: ACSL6_HUMAN

NCBI Description

The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6 gene are causes of myelodysplastic syndrome with basophilia, acute myelogenous leukemia with eosinophilia, and acute eosinophilic leukemia. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2011]

Uniprot Description

ACSL6: Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid. A chromosomal aberration involving ACSL6 may be a cause of myelodysplastic syndrome with basophilia. Translocation t(5;12)(q31;p13) with ETV6. A chromosomal aberration involving ACSL6 may be a cause of acute myelogenous leukemia with eosinophilia. Translocation t(5;12)(q31;p13) with ETV6. A chromosomal aberration involving ACSL6 may be a cause of acute eosinophilic leukemia (AEL). Translocation t(5;12)(q31;p13) with ETV6. Belongs to the ATP-dependent AMP-binding enzyme family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Ligase; Lipid Metabolism - fatty acid; EC 6.2.1.3

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: peroxisomal membrane; mitochondrial outer membrane; endoplasmic reticulum membrane; membrane; integral to membrane; plasma membrane; nucleus

Molecular Function: enzyme binding; protein homodimerization activity; ATP binding; long-chain-fatty-acid-CoA ligase activity

Biological Process: response to gravity; acyl-CoA metabolic process; cellular response to insulin stimulus; response to steroid hormone stimulus; neuroblast proliferation; response to hypoxia; neuron development; triacylglycerol biosynthetic process; cellular lipid metabolic process; long-chain fatty acid metabolic process; fatty acid transport; response to nutrient; phospholipid biosynthetic process