Western Blot (WB)
(ACSL4 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the ACSL4 antibody detected the ACSL4 protein (arrow).)
Rabbit ACSL4 Polyclonal Antibody | anti-ACSL4 antibody
ACSL4 Antibody (N-term)
Western Blot (WB)
(ACSL4 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the ACSL4 antibody detected the ACSL4 protein (arrow).)
Western Blot (WB)
(ACSL4 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the ACSL4 antibody detected the ACSL4 protein (arrow).)
long-chain fatty-acid-coenzyme A ligase family. Although differing
in substrate specificity, subcellular localization, and tissue
distribution, all isozymes of this family convert free long-chain
fatty acids into fatty acyl-CoA esters, and thereby play a key role
in lipid biosynthesis and fatty acid degradation. This isozyme
preferentially utilizes arachidonate as substrate. The absence of
this enzyme may contribute to the mental retardation or Alport
syndrome. Alternative splicing of this gene generates 2 transcript
variants.
Zhang, Y., et al. Hum. Mol. Genet. 18(20):3894-3905(2009)
Zeman, M., et al. Tohoku J. Exp. Med. 217(4):287-293(2009)
An, C., et al. Neurosci. Lett. 441(2):197-200(2008)
Hu, C., et al. Cancer Biol. Ther. 7(1):131-134(2008)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
Uniprot Description
ACSL4: Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates. Defects in ACSL4 are the cause of mental retardation X- linked type 63 (MRX63). Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non- syndromic mental retardation patients do not manifest other clinical signs. Defects in ACSL4 are involved in Alport syndrome with mental retardation midface hypoplasia and elliptocytosis (ATS-MR). A X-linked contiguous gene deletion syndrome characterized by glomerulonephritis, deafness, mental retardation, midface hypoplasia and elliptocytosis. Belongs to the ATP-dependent AMP-binding enzyme family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Lipid Metabolism - fatty acid; EC 6.2.1.3; Ligase
Chromosomal Location of Human Ortholog: Xq22.3-q23
Cellular Component: peroxisomal membrane; mitochondrial outer membrane; endoplasmic reticulum membrane; membrane; cell soma; cytoplasm; integral to membrane; lipid particle
Molecular Function: arachidonate-CoA ligase activity; very-long-chain-fatty-acid-CoA ligase activity; ATP binding; long-chain-fatty-acid-CoA ligase activity
Biological Process: embryonic process involved in female pregnancy; lipid biosynthetic process; triacylglycerol biosynthetic process; lipid metabolic process; long-chain fatty acid metabolic process; cellular lipid metabolic process; negative regulation of prostaglandin secretion; positive regulation of cell growth; fatty acid transport; response to nutrient
Disease: Mental Retardation, X-linked 63
Research Articles on ACSL4
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Product Notes
The ACSL4 acsl4 (Catalog #AAA9210752) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 28-56. The ACSL4 Antibody (N-term) reacts with Human (Predicted Reactivity: Mouse, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's ACSL4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the ACSL4 acsl4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ACSL4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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