Rabbit anti-Human, Rat ACMSD Polyclonal Antibody | anti-ACMSD antibody

ACMSD Antibody

Cat. Num. AAA7103646

• Reactivity: Human, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: >95%, Protein G purified
• Synonyms: ACMSD; Polyclonal Antibody; ACMSD Antibody; 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase1 Publication; Picolinate carboxylase; anti-ACMSD antibody

• Host: Rabbit
• Reactivity: Human, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G purified
• Form/Format: Liquid
• Sequence Length: 278

• Applicable Applications for anti-ACMSD antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: WB: 1:500-1:5000; IHC: 1:20-1:200; IF: 1:50-1:200
• Immunogen: Recombinant Human 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase protein (33-129AA)
• Conjugation: Non-conjugated
• Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
• Preparation and Storage: Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.

Western Blot (WB)

(Western BlotPositive WB detected in: Rat liver tissue, Rat heart tissueAll lanes: ACMSD antibody at 4ug/mlSecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 39, 32 KDaObserved band size: 39 KDa)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human liver cancer using MBS7103646 at dilution of 1:100)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human kidney tissue using MBS7103646 at dilution of 1:100)

Immunofluorescence (IF)

(Immunofluorescent analysis of HepG2 cells using MBS7103646 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))

Related Product Information for anti-ACMSD antibody

Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.

NCBI and Uniprot Product Information

• NCBI GI #: 808175905
• NCBI GeneID: 130013
• NCBI Accession #: NP_001294912.1
• NCBI GenBank Nucleotide #: NM_001307983.1
• UniProt Accession #: Q8TDX5; Q3B7X3; Q53SR5; Q96KY2
• Molecular Weight: 31,213 Da
• NCBI Official Full Name: 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase isoform 2
• NCBI Official Synonym Full Names: aminocarboxymuconate semialdehyde decarboxylase
• NCBI Official Symbol: ACMSD
• NCBI Protein Information: 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
• UniProt Protein Name: 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
• Protein Family: 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
• UniProt Gene Name: ACMSD

NCBI Description

The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.[supplied by OMIM, Oct 2004]

Uniprot Description

Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.