Western Blot (WB)
(Western Blot analysis of Raji cell using ACMSD Polyclonal Antibody at dilution of 1:400)
Rabbit ACMSD Polyclonal Antibody | anti-ACMSD antibody
ACMSD Polyclonal Antibody
Western Blot (WB)
(Western Blot analysis of Raji cell using ACMSD Polyclonal Antibody at dilution of 1:400)
Western Blot (WB)
(Western Blot analysis of Raji cell using ACMSD Polyclonal Antibody at dilution of 1:400)
NCBI and Uniprot Product Information
NCBI Description
The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.[supplied by OMIM, Oct 2004]
Uniprot Description
ACMSD: Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway. Belongs to the ACMSD family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Lyase; Amino Acid Metabolism - tryptophan; EC 4.1.1.45
Chromosomal Location of Human Ortholog: 2q21.3
Cellular Component: cytosol
Molecular Function: aminocarboxymuconate-semialdehyde decarboxylase activity; metal ion binding
Biological Process: quinolinate metabolic process; tryptophan catabolic process
Research Articles on ACMSD
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Product Notes
The ACMSD acmsd (Catalog #AAA2519381) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ACMSD Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's ACMSD can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). WB: 1:500-1:2000. Researchers should empirically determine the suitability of the ACMSD acmsd for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ACMSD, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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