Rabbit DUSP19 Polyclonal Antibody | anti-DUSP19 antibody

DUSP19 (F133) Polyclonal Antibody

Cat. Num. AAA3002477

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: DUSP19; Polyclonal Antibody; DUSP19 (F133) Polyclonal Antibody; Dual specificity protein phosphatase 19; Dual specificity phosphatase TS-DSP1; Low molecular weight dual specificity phosphatase 3; LMW-DSP3; Protein phosphatase SKRP1; Stress-activated protein kinase pathway-regulating phosphatase 1; SAPK pathway-regulating phosphatase 1; DUSP17; LMWDSP3; SKRP1; anti-DUSP19 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: DUSP19 (F133) polyclonal antibody detects endogenous levels of DUSP19 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 166

• Applicable Applications for anti-DUSP19 antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: WB: 1:500-1:1000; IHC: 1:50-1:200; IF: 1:50-1:200
• Immunogen: Synthetic peptide, corresponding to amino acids 100-150 of Human DUSP19.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of DUSP19 (F133) pAb at 1:500 dilutionLane1:Panc1 whole cell lysate (40ug) Lane2:L02 whole cell lysate (40ug) Lane3:H9C2 whole cell lysate (40ug) Lane4:AML-12 whole cell lysate (40ug))

Related Product Information for anti-DUSP19 antibody

Dual specificity phosphatases (DSPs) are a subclass of the protein tyrosine phosphatase (PTP) gene superfamily, which are selective for dephosphorylating critical phosphothreonine and phosphotyrosine residues within MAP kinases. DSP gene expression is induced by a host of growth factors and/or cellular stresses, thereby negatively regulating MAP kinase superfamily members including MAPK/ERK, SAPK/JNK and p38. The stress-activated protein kinase (SAPK) pathway-regulating phosphatase 1 (SKRP1) binds to MAP kinase MKK-7 to regulate JNK.

NCBI and Uniprot Product Information

• NCBI GI #: 214832050
• NCBI Accession #: NP_001135786.1
• NCBI GenBank Nucleotide #: NP_001135786.1
• UniProt Accession #: Q8WTR2
• Molecular Weight: ~ 28kDa
• NCBI Official Full Name: dual specificity protein phosphatase 19 isoform 2
• UniProt Protein Name: Dual specificity protein phosphatase 19
• Protein Family: Dual specificity protein phosphatase
• UniProt Gene Name: DUSP19
• UniProt Synonym Gene Names: DUSP17; LMWDSP3; SKRP1; LMW-DSP3
• UniProt Entry Name: DUS19_HUMAN

Uniprot Description

DUSP19: Has a dual specificity toward Ser/Thr and Tyr-containing proteins. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein phosphatase, dual-specificity; EC 3.1.3.48; EC 3.1.3.16; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q32.1

Cellular Component: cytoplasm

Molecular Function: protein tyrosine/threonine phosphatase activity; JUN kinase phosphatase activity; MAP-kinase scaffold activity; protein kinase inhibitor activity; protein tyrosine phosphatase activity; mitogen-activated protein kinase kinase kinase binding; protein kinase activator activity

Biological Process: positive regulation of JNK activity; negative regulation of JNK cascade; negative regulation of JNK activity; positive regulation of MAPKKK cascade; positive regulation of protein kinase activity; JNK cascade; negative regulation of protein kinase activity; positive regulation of JNK cascade; protein amino acid dephosphorylation; inactivation of MAPK activity