Rabbit ABCB8 Polyclonal Antibody | anti-ABCB8 antibody

ABCB8

Cat. Num. AAA126552

• Gene Names: ABCB8; MABC1; M-ABC1; EST328128
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Synonyms: ABCB8; Polyclonal Antibody; anti-ABCB8 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Sequence Length: 735

• Applicable Applications for anti-ABCB8 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Species: Human
• Immunogen: Recombinant Protein

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using ABCB8 antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 5s.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human liver injury using ABCB8 antibody at dilution of 1:100 (40x lens).)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded rat brain using ABCB8 antibody at dilution of 1:100 (40x lens).)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded mouse heart using ABCB8 antibody at dilution of 1:100 (40x lens).)

Product Categories/Family for anti-ABCB8 antibody

Polyclonal

NCBI and Uniprot Product Information

• NCBI GI #: 143811358
• NCBI GeneID: 11194
• UniProt Accession #: Q9NUT2; O95787; Q53GM0; A5D8W3; B2RBL8; B3KND2; B4DG02; G3XAP3
• Molecular Weight: 718
• NCBI Official Full Name: ATP-binding cassette sub-family B member 8, mitochondrial
• NCBI Official Synonym Full Names: ATP-binding cassette, sub-family B (MDR/TAP), member 8
• NCBI Official Symbol: ABCB8
• NCBI Official Synonym Symbols: MABC1; M-ABC1; EST328128
• NCBI Protein Information: ATP-binding cassette sub-family B member 8, mitochondrial; mitochondrial ABC protein; mitochondrial ATP-binding cassette 1
• UniProt Protein Name: ATP-binding cassette sub-family B member 8, mitochondrial
• Protein Family: ATP-binding cassette sub-family
• UniProt Gene Name: ABCB8
• UniProt Synonym Gene Names: MABC1; M-ABC1
• UniProt Entry Name: ABCB8_HUMAN

NCBI Description

This nuclear gene encodes a multi-pass membrane protein that is targeted to the mitochondrial inner membrane. The encoded protein is an ATP-dependent transporter that may mediate the passage of organic and inorganic molecules out of the mitochondria. Loss of function of the related gene in mouse results in a disruption of iron homeostasis between the mitochondria and cytosol. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Uniprot Description

ABCB8: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, it may involve the compartmentalization and transport of heme, as well as peptides, from the mitochondria to the nucleus and cytosol. This protein may also play a role in the transport of phospholipids into mitochondrial membranes. [provided by RefSeq, Jul 2008]

Protein type: Hydrolase; Transporter, ABC family; Membrane protein, integral; Mitochondrial; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 7q36

Cellular Component: mitochondrial envelope; mitochondrion; membrane; mitochondrial inner membrane; integral to membrane; nucleolus; ATP-binding cassette (ABC) transporter complex; nucleus

Molecular Function: transporter activity; ATPase activity, coupled to transmembrane movement of substances; ATP binding

Biological Process: transport; metabolic process; transmembrane transport